CAJ | 학술논문

目的：探讨辅助生殖技术(ART)治疗后流产的发生率及其相关因素。方法回顾性分析2009年1月至2012年6月在本中心行体外授精-胚胎移植(IVF-ET)治疗后妊娠的166例孕妇的临床资料，根据是否自然流产分为流产组(n=35)和对照组(n=131)，比较两组患者年龄、不孕年限、基础内分泌、促性腺激素使用天数(Gn天数)，促性腺激素使用总量(Gn总量)、获卵个数、受精方式、内膜厚度等的差异，分析可能影响妊娠结局的因素。结果流产组患者年龄较对照组高，促排卵药物(Gn)使用总量多于对照组，基础FSH水平高于对照组，获卵数低于对照组，上述指标比较差异均有统计学意义(P<0.05)，两组的不孕年限、内膜厚度比较差异均无统计学意义(P>0.05)，单精子卵胞浆内显微注射(ICSI)组中流产率低于IVF组流产率，差异有统计学意义(P<0.05)。结论引起IVF-ET早期妊娠丢失的原因复杂，可能与患者年龄、基础FSH水平、Gn总量等因素相关。
목적：탐토보조생식기술(ART)치료후유산적발생솔급기상관인소。방법회고성분석2009년1월지2012년6월재본중심행체외수정-배태이식(IVF-ET)치료후임신적166례잉부적림상자료，근거시부자연유산분위유산조(n=35)화대조조(n=131)，비교량조환자년령、불잉년한、기출내분비、촉성선격소사용천수(Gn천수)，촉성선격소사용총량(Gn총량)、획란개수、수정방식、내막후도등적차이，분석가능영향임신결국적인소。결과유산조환자년령교대조조고，촉배란약물(Gn)사용총량다우대조조，기출FSH수평고우대조조，획란수저우대조조，상술지표비교차이균유통계학의의(P<0.05)，량조적불잉년한、내막후도비교차이균무통계학의의(P>0.05)，단정자란포장내현미주사(ICSI)조중유산솔저우IVF조유산솔，차이유통계학의의(P<0.05)。결론인기IVF-ET조기임신주실적원인복잡，가능여환자년령、기출FSH수평、Gn총량등인소상관。
Objective To discuss the incidence of early spontaneous abortion and its related factors after as-sisted reproductive technology (ART). Methods The clinical data of 166 pregnant women undergoing in vitro fertil-ization and embryo transfer (IVF-ET) from January 2009 to June 2012 in our department were retrospectively ana-lyzed, which were divided into spontaneous abortion group (n=35, women suffered early spontaneous abortion) and the control group (n=131, women with successfully pregnancy). Difference of the age, infertility time, basic endo-crine, days of using Gonadoropin (Gn Days), the total amount of Gonadotropin (total amount of Gn), the number of re-trieved oocytes, fertilization method, the intimal thickness were compared between the two groups. The related factors affecting the pregnancy outcome were analyzed. Results Compared with the control group, the average age of the pa-tients in spontaneous abortion group were significantly higher, the total amount of Gn significantly more, the level of FSH was significantly higher, the number of retrieved oocyte was significantly less, all with statistically significant dif-ference (P<0.05). The infertility time and the endometrium thickness showed no statistically significant difference be-tween the two groups (P>0.05). The abortion frequency treated by intacytoplamicsperm injection (ICSI) were signifi-cantly lower than that treated by IVF (P<0.05). Conclusion The factors that effect early abortion after IVF-ET are complex, which might include age, basic FSH level, and the total amount of Gn.