CAJ | 학술논문

目的：探讨类风湿因子（RF）、抗环状瓜氨酸肽抗体（Anti-CCP）与患者临床免疫学特征之间存在的相关性。方法选取2012年5月至2014年7月在该院门诊就诊及住院的178例类风湿关节炎患者作为研究对象，并对患者的 RF、Anti-CCP 两项指标进行检测。结果患者中 RF 呈现阳性的比例为94.94％（169／178），Anti-CCP 呈现阳性的比例为79.78％（142／178）；病程超过1年患者占73.03％（130／178），类风湿关节炎患者的病程与 Anti-CCP 抗体现阳性率呈相关（P ＜0.05），与 RF 阳性率不存在相关性（P ＞0.05）。结论类风湿因子特异性较弱，抗环状瓜氨酸肽抗体（Anti-CCP）特异性突出，对早期诊断和临床治疗中发挥着极大的作用和价值，并和类风湿关节炎患者病情的严重性存在正相关关系。
목적：탐토류풍습인자（RF）、항배상과안산태항체（Anti-CCP）여환자림상면역학특정지간존재적상관성。방법선취2012년5월지2014년7월재해원문진취진급주원적178례류풍습관절염환자작위연구대상，병대환자적 RF、Anti-CCP 량항지표진행검측。결과환자중 RF 정현양성적비례위94.94％（169／178），Anti-CCP 정현양성적비례위79.78％（142／178）；병정초과1년환자점73.03％（130／178），류풍습관절염환자적병정여 Anti-CCP 항체현양성솔정상관（P ＜0.05），여 RF 양성솔불존재상관성（P ＞0.05）。결론류풍습인자특이성교약，항배상과안산태항체（Anti-CCP）특이성돌출，대조기진단화림상치료중발휘착겁대적작용화개치，병화류풍습관절염환자병정적엄중성존재정상관관계。
Objective To explore and evaluate the relationship between rheumatoid factor(RF)and anti-cyclic citrullinated pep-tide antibody(anti-CCP)with the patient′s immunological characteristics.Methods 178 patients with rheumatoid arthritis in our hospital from May 2012 to May 2014 were selected as the research subjects and detected the various clinical indicators.Results A-mong the patients,the proportion of RF positive was 94.94%(169/178)and which of anti-CCP positive was 79.78%(142/178);the cases of disease course for more than 1 year accounted for 73.03%(130/178),which had the correlation with the proportion of anti-CCP positive(P <0.05),and RF had no correlation(P >0.05).Conclusion RF has weaker specificity and anti-CCP antibody has prominent specificity,which play an enormous role and great value for early diagnosis and treatment,and have a positive correlation with the severity of rheumatoid arthritis.