CAJ | 학술논문

目的：探讨不同性别冠心病患者脂蛋白（a）与纤维蛋白原的表达及其临床意义。方法选取该院2009年1月至2013年12月诊治的冠心病患者1500例为观察组，其中男954例，女546例。选取该院同期健康体检人员500例为对照组，其中男329例，女171例。均行心肌酶谱、血脂、凝血功能及多种蛋白检测。结果无论是男性还是女性，观察组患者 CK、CKMB、AST、LDH、α-HBDH、TC、TG、LDL-C、FIb、D-D、TT、FDP、LPa、cTnI、MYO、HCY 均明显高于对照组，观察组患者 HDL-C、APTT、INR、PT 均明显低于对照组，差异均有统计学意义（P ＜0.05）。结论无论是男性还是女性，冠心病患者均存在不同程度的心肌酶谱指标、血脂指标、凝血功能指标、载脂蛋白、肌钙蛋白、肌红蛋白和同型半胱氨酸异常表达。脂蛋白（a）与纤维蛋白原在冠心病患者中存在高表达，可为患者疾病的诊治提供可靠的科学依据。
목적：탐토불동성별관심병환자지단백（a）여섬유단백원적표체급기림상의의。방법선취해원2009년1월지2013년12월진치적관심병환자1500례위관찰조，기중남954례，녀546례。선취해원동기건강체검인원500례위대조조，기중남329례，녀171례。균행심기매보、혈지、응혈공능급다충단백검측。결과무론시남성환시녀성，관찰조환자 CK、CKMB、AST、LDH、α-HBDH、TC、TG、LDL-C、FIb、D-D、TT、FDP、LPa、cTnI、MYO、HCY 균명현고우대조조，관찰조환자 HDL-C、APTT、INR、PT 균명현저우대조조，차이균유통계학의의（P ＜0.05）。결론무론시남성환시녀성，관심병환자균존재불동정도적심기매보지표、혈지지표、응혈공능지표、재지단백、기개단백、기홍단백화동형반광안산이상표체。지단백（a）여섬유단백원재관심병환자중존재고표체，가위환자질병적진치제공가고적과학의거。
Objective To investigate the expression of lipoprotein(a)and fibrinogen different genders of patients with coronary heart disease(CHD)and its clinical significance.Methods 1 500 patients with CHD in the hospital from January 2009 to December 2013 were selected as the observation group,including 954 males and 546 females.Contemporaneous 500 healthy people with physi-cal examination were selected as the control group,including 329 males and 171 females.The myocardial enzymes,serum lipid,blood coagulation function and various proteins were detected.Results Whether males or females,CK,CKMB,AST,LDH,α-HBDH, TC,TG,LDL-C,Fib,D-D,TT,FDP,LPa,cTnI,MYO and HCY in the observation group were significantly higher than those in the control group.HDL-C,APTT,INR and PT in the observation group were significantly lower than those in the control group.The differences were statistically significant(P <0.05 ).Conclusion Whether males or females,the different degrees of abnormal ex-pression of myocardial enzyme spectral indexes,blood lipid indexes,coagulation indexes,apolipoprotein,troponin,myoglobin and ho-mocysteine exist in the patients with CHD.Lipoprotein(a)and fibrinogen have high expression in the CHD patients,which can pro-vide the reliable scientific basis for diagnosis and treatment of the disease.