中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2014年
35期
29-30,31
,共3页
曲美他嗪%单硝酸异山梨酯片%冠心病%心绞痛
麯美他嗪%單硝痠異山梨酯片%冠心病%心絞痛
곡미타진%단초산이산리지편%관심병%심교통
Trimetazidine%Isosorbide Mononitrate Tablets%Coronary heart disease%Angina
目的：探讨盐酸曲美他嗪治疗老年冠心病患者的疗效，并与单硝酸异山梨酯片的治疗效果进行对比，以期为临床治疗老年冠心病提供依据。方法：选取笔者所在医院2009年1月-2011年1月收治的符合慢性稳定型心绞痛诊断标准的90例患者，按照随机数字表法将其分为曲美他嗪组和硝酸异山梨酯片组各45例。在常规治疗的基础上，曲美他嗪组加用盐酸曲美他嗪片治疗，硝酸异山梨酯片组加用单硝酸异山梨酯片治疗，3个月为一疗程。治疗3个月后，分别统计两组患者的心绞痛发作时间、发作的频率及心电图改变资料，并对所得数据进行统计学分析，观察比较两组患者的临床疗效和心电图疗效。结果：经治疗后，曲美他嗪组的治疗总有效率82.22%明显高于硝酸异山梨酯片组的57.78%，心电图总有效率77.78%明显高于硝酸异山梨酯片组的51.11%，差异均有统计学意义(P<0.05)。两组治疗期间均未发生不良反应。结论：曲美他嗪是一种新型的治疗老年冠心病的药物，其治疗效果明显优于传统的治疗药物，是临床治疗老年冠心病用药的一个新选择，值得临床广泛推广。
目的：探討鹽痠麯美他嗪治療老年冠心病患者的療效，併與單硝痠異山梨酯片的治療效果進行對比，以期為臨床治療老年冠心病提供依據。方法：選取筆者所在醫院2009年1月-2011年1月收治的符閤慢性穩定型心絞痛診斷標準的90例患者，按照隨機數字錶法將其分為麯美他嗪組和硝痠異山梨酯片組各45例。在常規治療的基礎上，麯美他嗪組加用鹽痠麯美他嗪片治療，硝痠異山梨酯片組加用單硝痠異山梨酯片治療，3箇月為一療程。治療3箇月後，分彆統計兩組患者的心絞痛髮作時間、髮作的頻率及心電圖改變資料，併對所得數據進行統計學分析，觀察比較兩組患者的臨床療效和心電圖療效。結果：經治療後，麯美他嗪組的治療總有效率82.22%明顯高于硝痠異山梨酯片組的57.78%，心電圖總有效率77.78%明顯高于硝痠異山梨酯片組的51.11%，差異均有統計學意義(P<0.05)。兩組治療期間均未髮生不良反應。結論：麯美他嗪是一種新型的治療老年冠心病的藥物，其治療效果明顯優于傳統的治療藥物，是臨床治療老年冠心病用藥的一箇新選擇，值得臨床廣汎推廣。
목적：탐토염산곡미타진치료노년관심병환자적료효，병여단초산이산리지편적치료효과진행대비，이기위림상치료노년관심병제공의거。방법：선취필자소재의원2009년1월-2011년1월수치적부합만성은정형심교통진단표준적90례환자，안조수궤수자표법장기분위곡미타진조화초산이산리지편조각45례。재상규치료적기출상，곡미타진조가용염산곡미타진편치료，초산이산리지편조가용단초산이산리지편치료，3개월위일료정。치료3개월후，분별통계량조환자적심교통발작시간、발작적빈솔급심전도개변자료，병대소득수거진행통계학분석，관찰비교량조환자적림상료효화심전도료효。결과：경치료후，곡미타진조적치료총유효솔82.22%명현고우초산이산리지편조적57.78%，심전도총유효솔77.78%명현고우초산이산리지편조적51.11%，차이균유통계학의의(P<0.05)。량조치료기간균미발생불량반응。결론：곡미타진시일충신형적치료노년관심병적약물，기치료효과명현우우전통적치료약물，시림상치료노년관심병용약적일개신선택，치득림상엄범추엄。
Objective:To investigate the clinical efficacy of Trimetazidine in the treatment of elderly patients with coronary heart disease,and compare with the clinical efficacy of Isosorbide Mononitrate Tablets,in order to provide basis for clinical treatment of senile coronary heart disease.Method:90 patients who consistent with the diagnosis of chronic stable angina standard admitted to our hospital from January 2009 to January 2011 were selected,they were divided into the Trimetazidine group and the Isosorbide Dinitrate Tablet group according to the random number table method,45 cases in each group.On the basis of conventional therapy,the Trimetazidine group was given Trimetazidine Dihydrochloride Tablets for treatment,the Isosorbide Dinitrate Tablet group was given Isosorbide Mononitrate Tablets for treatment,a treatment course was 3 month.After 3 months of treatment,the data of angina pectoris attack time,frequency and ECG changes in the two groups were statistically analyzed,the clinical effect and electrocardiogram efficacy between the two groups were observed and compared. Result:After treatment,the total effective rate of Trimetazidine group was 82.22%,it was significantly higher than 57.78%of Isosorbide Dinitrate Tablet group, and the total effective rate of electrocardiogram in Trimetazidine group was 77.78%,it was significantly higher than 51.11%of Isosorbide Dinitrate Tablet group, the differences were statistically significant(P<0.05).The two groups were no adverse reaction during the treatment period.Conclusion:Trimetazidine is a new type of treatment of senile coronary heart disease,its curative effect is obviously superior to the traditional drug treatment,is a new choice for clinical treatment of senile coronary heart disease medication,is worthy of clinical widely promotion.
