中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2014年
35期
27-28
,共2页
糖尿病周围神经病%前列地尔%甲钴胺
糖尿病週圍神經病%前列地爾%甲鈷胺
당뇨병주위신경병%전렬지이%갑고알
Diabetic peripheral neuropathy%Alprostadil%Mecobalamine
目的：观察前列地尔联合甲钴胺治疗糖尿病周围神经病变的疗效。方法：选取2012年3月-2013年7月收治于笔者所在科室的52例糖尿病并发周围神经病变患者，按照随机数字表法将其分为观察组和对照组各26例，在血糖控制满意的基础上，两组均给予静脉注射前列地尔10μg，1次/d，观察组在此基础上给予肌肉注射甲钴胺500μg，1次/d，疗程均为2周。于一疗程治疗结束后，观察比较两组患者的疗效、治疗前后血液流变学及血脂指标变化情况。结果：经治疗后，观察组的治疗总有效率92.3%(24/26)明显高于对照组的57.7%(15/26)，差异有统计学意义(χ2=11.724，P=0.000)。观察组治疗后的血液流变学和血脂指标均明显低于治疗前和对照组，差异均有统计学意义(P<0.05)。结论：采用前列地尔联合甲钴胺治疗糖尿病周围神经病的疗效显著，能更好地恢复周围神经，且副作用小，方便安全，值得临床推广。
目的：觀察前列地爾聯閤甲鈷胺治療糖尿病週圍神經病變的療效。方法：選取2012年3月-2013年7月收治于筆者所在科室的52例糖尿病併髮週圍神經病變患者，按照隨機數字錶法將其分為觀察組和對照組各26例，在血糖控製滿意的基礎上，兩組均給予靜脈註射前列地爾10μg，1次/d，觀察組在此基礎上給予肌肉註射甲鈷胺500μg，1次/d，療程均為2週。于一療程治療結束後，觀察比較兩組患者的療效、治療前後血液流變學及血脂指標變化情況。結果：經治療後，觀察組的治療總有效率92.3%(24/26)明顯高于對照組的57.7%(15/26)，差異有統計學意義(χ2=11.724，P=0.000)。觀察組治療後的血液流變學和血脂指標均明顯低于治療前和對照組，差異均有統計學意義(P<0.05)。結論：採用前列地爾聯閤甲鈷胺治療糖尿病週圍神經病的療效顯著，能更好地恢複週圍神經，且副作用小，方便安全，值得臨床推廣。
목적：관찰전렬지이연합갑고알치료당뇨병주위신경병변적료효。방법：선취2012년3월-2013년7월수치우필자소재과실적52례당뇨병병발주위신경병변환자，안조수궤수자표법장기분위관찰조화대조조각26례，재혈당공제만의적기출상，량조균급여정맥주사전렬지이10μg，1차/d，관찰조재차기출상급여기육주사갑고알500μg，1차/d，료정균위2주。우일료정치료결속후，관찰비교량조환자적료효、치료전후혈액류변학급혈지지표변화정황。결과：경치료후，관찰조적치료총유효솔92.3%(24/26)명현고우대조조적57.7%(15/26)，차이유통계학의의(χ2=11.724，P=0.000)。관찰조치료후적혈액류변학화혈지지표균명현저우치료전화대조조，차이균유통계학의의(P<0.05)。결론：채용전렬지이연합갑고알치료당뇨병주위신경병적료효현저，능경호지회복주위신경，차부작용소，방편안전，치득림상추엄。
Objective:To observe the efficacy of Alprostadil combined with Mecobalamine in the treatment of diabetic peripheral neuropathy. Method:52 patients with diabetes complicating with DPN admitted to our department from March 2012 to July 2013 were selected,they were randomly divided into the observation group and the control group according to the random number table method,26 cases in each group.On the basis of satisfactory glycemic control, the two groups were given Alprostadil 10μg via intravenous injection once a day,the observation group was given Mecobalamine 500μg via intramuscular injection once a day on the basis of control group.Both groups were treated for 2 weeks.After a course of treatment,the clinical efficacy and changes of hemorheology and blood lipid indexes before and after treatment were observed and compared.Result:After treatment,the total effective rate of observation group was 92.3%(24/26),it was significantly higher than 57.7%(15/26) of control group,the difference was statistically significant(χ 2=11.724,P=0.000).The hemorheology and blood lipid indexes of observation group after treatment were significantly lower than before treatment and the control group,the differences were statistically significant(P<0.05).Conclusion:The curative effect of Alprostadil combined Mecobalamine in the treatment of DPN is remarkable,can better recover peripheral nerve,and the side effect is small,convenient and safe,is worthy of clinical promotion.
