医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2014年
37期
85-85
,共1页
糖尿病%尿微量白蛋白%糖化血红蛋白%尿酸
糖尿病%尿微量白蛋白%糖化血紅蛋白%尿痠
당뇨병%뇨미량백단백%당화혈홍단백%뇨산
Diabetes%Mel itus,microalbuminuria%Glycated hemoglobin%Uric acid
目的：研究糖尿病肾病(DN)患者尿微量白蛋白(mAlb)、糖化血红蛋白(HbA1c)、尿蛋白(U-Pro)、尿素氮(Bun)及尿酸(UA)的水平变化及检测的临床应用价值。方法收集175例T2DM患者,年龄(61.5±10.5)岁，根据24h尿mAlb分为两组：A组105例(<30mg/24h),B组70例(≥30mg/24h)。另选60例健康体检者为对照组(NC)。检测三组mAlb、HbA1c、空腹血糖(FBG)、Bun、Cr、U-Pro和UA的水平。结果 NC组、A组与B组的mAlb、FBG、HbA1c、Bun、UA和U-Pro含量均呈递增趋势，A组的FBG、HbA1c、Bun、UA和U-Pro均高于NC组(<0.05)。 B组的HbA1c、UA和U-Pro与NC组比较均呈显著性升高(<0.01)；B组的FBG、BuN和Cr也高于NC组(<0.05)。 B组的HbA1c、UA和U-Pro均高于NAU组(<0.05)。异常UA检出率与mAlb的排出量成正相关，异常Bun和异常Cr检出率在mAlb的排出量高的组中有一定程度的增高。结论 T2DM合并肾病患者时24h尿mAlb、HbA1c、U-Pro、FBG、Bun、UA的水平升高，因此应重视其水平的检测。T2DM患者中并发DN患者比无DN的患者存在UA代谢异常的几率更大更严重。24h尿mAlb超过30mg/24h时DM患者血UA(≥430umol/L)的概率高达20%。
目的：研究糖尿病腎病(DN)患者尿微量白蛋白(mAlb)、糖化血紅蛋白(HbA1c)、尿蛋白(U-Pro)、尿素氮(Bun)及尿痠(UA)的水平變化及檢測的臨床應用價值。方法收集175例T2DM患者,年齡(61.5±10.5)歲，根據24h尿mAlb分為兩組：A組105例(<30mg/24h),B組70例(≥30mg/24h)。另選60例健康體檢者為對照組(NC)。檢測三組mAlb、HbA1c、空腹血糖(FBG)、Bun、Cr、U-Pro和UA的水平。結果 NC組、A組與B組的mAlb、FBG、HbA1c、Bun、UA和U-Pro含量均呈遞增趨勢，A組的FBG、HbA1c、Bun、UA和U-Pro均高于NC組(<0.05)。 B組的HbA1c、UA和U-Pro與NC組比較均呈顯著性升高(<0.01)；B組的FBG、BuN和Cr也高于NC組(<0.05)。 B組的HbA1c、UA和U-Pro均高于NAU組(<0.05)。異常UA檢齣率與mAlb的排齣量成正相關，異常Bun和異常Cr檢齣率在mAlb的排齣量高的組中有一定程度的增高。結論 T2DM閤併腎病患者時24h尿mAlb、HbA1c、U-Pro、FBG、Bun、UA的水平升高，因此應重視其水平的檢測。T2DM患者中併髮DN患者比無DN的患者存在UA代謝異常的幾率更大更嚴重。24h尿mAlb超過30mg/24h時DM患者血UA(≥430umol/L)的概率高達20%。
목적：연구당뇨병신병(DN)환자뇨미량백단백(mAlb)、당화혈홍단백(HbA1c)、뇨단백(U-Pro)、뇨소담(Bun)급뇨산(UA)적수평변화급검측적림상응용개치。방법수집175례T2DM환자,년령(61.5±10.5)세，근거24h뇨mAlb분위량조：A조105례(<30mg/24h),B조70례(≥30mg/24h)。령선60례건강체검자위대조조(NC)。검측삼조mAlb、HbA1c、공복혈당(FBG)、Bun、Cr、U-Pro화UA적수평。결과 NC조、A조여B조적mAlb、FBG、HbA1c、Bun、UA화U-Pro함량균정체증추세，A조적FBG、HbA1c、Bun、UA화U-Pro균고우NC조(<0.05)。 B조적HbA1c、UA화U-Pro여NC조비교균정현저성승고(<0.01)；B조적FBG、BuN화Cr야고우NC조(<0.05)。 B조적HbA1c、UA화U-Pro균고우NAU조(<0.05)。이상UA검출솔여mAlb적배출량성정상관，이상Bun화이상Cr검출솔재mAlb적배출량고적조중유일정정도적증고。결론 T2DM합병신병환자시24h뇨mAlb、HbA1c、U-Pro、FBG、Bun、UA적수평승고，인차응중시기수평적검측。T2DM환자중병발DN환자비무DN적환자존재UA대사이상적궤솔경대경엄중。24h뇨mAlb초과30mg/24h시DM환자혈UA(≥430umol/L)적개솔고체20%。
Objective Study of diabetic nephropathy (DN) patients urine albumin (mAlb trace), glycated hemoglobin (HbA1c), urinary protein (U-Pro), Pro-urea nitrogen (Bun) and uric acid (UA) level change and testing value of clinical application.Methods 175 cases of high-risk T2DM patients with (61.5±10.5)years old as cases group. According to mAlb 24h urine into two groups: A group with105 patients (<30mg/24h) and B group with 70 patients (≥30mg/24h). Swap 60 patients healthy check-up for the control group (NC). Detection three groups mAlb, HbA1c, fasting blood sugar (FBG), Bun, Cr, U-Pro and the level of UA its clinical application value and analysis. Results NC group, with maus of A and B groups of HbA1c, Bun, FBG, UA and U-Pro content increasing trend. In NAU group the FBG, HbA1c , Bun, UA and U-Pro are already higher than NC group ( <0.05). The level of HbA1c, UA and U-Pro in B group al were significantly increased compared with NC group (p<0.01);In B group the FBG, Bun and Cr are already higher than NC group ( <0.05). In MAU group the HbA1c, UA and U-Pro are already higher than A group ( <0.05).Anomaly delection of UA and mAlb of discharge rate compared with a positive cor elation. Abnormal Bun and abnormal Cr rate of the amount of mAlb discharge with too many increased to a certain extent. Conclusion T2DM patients with kidney disease when 24 hours mAlb HbA1c, urine, U-Pro, FBG, Bun, UA elevated levels of, so should at ach importance to their level of detection. High-risk T2DM patients than in patients without DN UA metabolic abnormalities of the patients have more likely the more serious.mAlb 24h urine 30mg/24h over when the probability of UA (≥430umol/L)DM is patients blood to 20%.
