医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2014年
38期
105-105
,共1页
邓倩%庞金玲%王靖飞%戚惠君%王淑英
鄧倩%龐金玲%王靖飛%慼惠君%王淑英
산천%방금령%왕정비%척혜군%왕숙영
淫羊藿苷%东莨菪碱%学习记忆障碍%保护作用
淫羊藿苷%東莨菪堿%學習記憶障礙%保護作用
음양곽감%동랑탕감%학습기억장애%보호작용
Icari n%Scopolamine%Learning and memory disorder%Protective ef ect
目的探讨淫羊藿苷(ICA)对东莨菪碱所致学习记忆障碍小鼠的保护作用。方法40只小鼠随机分为4组(对照组,模型组,ICA低、高剂量组)。连续给药10d,通过自主活动、Mor is水迷宫实验检测学习记忆能力的改变。结果 ICA可以改善记忆障碍小鼠的自主活动次数、空间探索能力以及定位航行能力,缩短小鼠在空间探索及定位航行实验的潜伏期。结论淫羊藿苷可改善东莨菪碱所致小鼠的学习记忆障碍。
目的探討淫羊藿苷(ICA)對東莨菪堿所緻學習記憶障礙小鼠的保護作用。方法40隻小鼠隨機分為4組(對照組,模型組,ICA低、高劑量組)。連續給藥10d,通過自主活動、Mor is水迷宮實驗檢測學習記憶能力的改變。結果 ICA可以改善記憶障礙小鼠的自主活動次數、空間探索能力以及定位航行能力,縮短小鼠在空間探索及定位航行實驗的潛伏期。結論淫羊藿苷可改善東莨菪堿所緻小鼠的學習記憶障礙。
목적탐토음양곽감(ICA)대동랑탕감소치학습기억장애소서적보호작용。방법40지소서수궤분위4조(대조조,모형조,ICA저、고제량조)。련속급약10d,통과자주활동、Mor is수미궁실험검측학습기억능력적개변。결과 ICA가이개선기억장애소서적자주활동차수、공간탐색능력이급정위항행능력,축단소서재공간탐색급정위항행실험적잠복기。결론음양곽감가개선동랑탕감소치소서적학습기억장애。
Objective To discussion Protective ef ect of icari a(ICA) on learning and memory dysfunction by scopolamine-induced in mice.Methods The experimental mice were randomly divided into model group, scopolamine, low and high dose of ICA, Gavage 10d, through independent activity experiment, Morris water maze experiment to detect the changes of learning and memory ability.Results ICA may improve scopolamine-induced locomotor activity in mice , space exploration capabilities and the ability to place navigation, space exploration and shortened mouse navigation test incubation period. Conclusion Icari n could improve the learning and memory impairment induced by scopolamine in mice.
