CAJ | 학술논문

目的评估超声造影(CEUS)在肝细胞癌(HCC)行射频消融(RFA)治疗前后的应用价值。方法选取2011年4月~2012年4月于南京市鼓楼医院普外科行RFA治疗HCC患者共24例。术前及术后1个月所有患者常规行CEUS评估，术前计算病灶达峰时间(TTP)与峰值强度(PI)，术后判断消融毁损程度。结果肿瘤病灶TTP与血清血管内皮生长因子(VEGF)呈负相关，与肿瘤组织分化程度负相关。 PI与肿瘤相关指标间无明显相关。术后6例患者行CEUS评估示病灶消融不全，与CT/MRI表现及治疗前后肿瘤指标改变相符。结论 CEUS是RFA治疗前后重要的影像评估手段。
목적평고초성조영(CEUS)재간세포암(HCC)행사빈소융(RFA)치료전후적응용개치。방법선취2011년4월~2012년4월우남경시고루의원보외과행RFA치료HCC환자공24례。술전급술후1개월소유환자상규행CEUS평고，술전계산병조체봉시간(TTP)여봉치강도(PI)，술후판단소융훼손정도。결과종류병조TTP여혈청혈관내피생장인자(VEGF)정부상관，여종류조직분화정도부상관。 PI여종류상관지표간무명현상관。술후6례환자행CEUS평고시병조소융불전，여CT/MRI표현급치료전후종류지표개변상부。결론 CEUS시RFA치료전후중요적영상평고수단。
Objective To evaluate the application of contrast-enhanced ultrasonography (CEUS)in Hepatocel ular Carcinoma Undergoing Radiofrequency Ablation.Methods Twenty-four patients with hepatocel ular carcinoma (HCC)undergoing radiofrequency ablation (RFA)in Nanjing Drum Tower Hospital during April 2011 and April 2012 were included in our study.Al patients were routinely examined with CEUS before and 1 month after RFA.Time to peak (TTP)and peak intensity (PI)were calculated during the pre-RFA evaluation and CEUS was used to assess the completeness of RFA 1 month after.Results TTP,instead of PI,was negatively cor elated with serum vascular endothelial growth factor(VEGF)and tumor dif erention degree in HCC patients.1 month after RFA,6 patients showed sign of incomplete ablation on CEUS which was in consistency with CT or MRI findings.Conclusion CEUS is an ef ective method to assess the biological behavior of HCC before RFA and the completeness of ablation after RFA.