CAJ | 학술논문

目的分析比较多西他赛(DTX)为主的两种联合方案治疗晚期胃癌的有效性及安全性。方法收集自2011年3月~2013年12月在我院肿瘤内科和普外科住院化疗的晚期胃癌患者119例,均为初次使用紫杉类药物化疗,47例患者分入DCF组(DTX75mg/㎡,静滴d1,DDP20mg/㎡,静滴d1~d3,5-FU400 mg/㎡静滴d1~d5,LV300mg,静滴d1~d5,q3w；)和72例患者分入DC(DTX75mg/㎡,静滴d1,DDP20mg/㎡,静滴d1~d3,q3w)组。化疗2周期后评价疗效及毒副反应。结果全部入组病例均可评价近期疗效和毒副反应。DCF组与DC组的近期有效率(RR)比较无统计学意义(跃0.05)；疾病控制率(DCR)相似,差别无显著性(P跃0.05)；两组患者的毒副反应均能耐受,两组化疗方案的3~4级毒副反应方面比较,神经毒素及肌痛差异无显著性(跃0.05),白细胞减少水平、恶心、呕吐、乏力、腹泻的3~4级不良反应发生率DCF组明显高于DC组,差异有显著性(<0.05)。结论在晚期胃癌的治疗中,化疗方案DCF与DC疗效相似,但两药方案患者耐受性更好,毒副作用更低。
목적분석비교다서타새(DTX)위주적량충연합방안치료만기위암적유효성급안전성。방법수집자2011년3월~2013년12월재아원종류내과화보외과주원화료적만기위암환자119례,균위초차사용자삼류약물화료,47례환자분입DCF조(DTX75mg/㎡,정적d1,DDP20mg/㎡,정적d1~d3,5-FU400 mg/㎡정적d1~d5,LV300mg,정적d1~d5,q3w；)화72례환자분입DC(DTX75mg/㎡,정적d1,DDP20mg/㎡,정적d1~d3,q3w)조。화료2주기후평개료효급독부반응。결과전부입조병례균가평개근기료효화독부반응。DCF조여DC조적근기유효솔(RR)비교무통계학의의(약0.05)；질병공제솔(DCR)상사,차별무현저성(P약0.05)；량조환자적독부반응균능내수,량조화료방안적3~4급독부반응방면비교,신경독소급기통차이무현저성(약0.05),백세포감소수평、악심、구토、핍력、복사적3~4급불량반응발생솔DCF조명현고우DC조,차이유현저성(<0.05)。결론재만기위암적치료중,화료방안DCF여DC료효상사,단량약방안환자내수성경호,독부작용경저。
Objective To compare and analyze the ef icacy and safety of docetaxel -containing regimen for patients with advanced gastric cancer. Methods Col ect 119 patients with advanced gastric cancer treated by chemotherapy in General surgery and Oncology from march 2011 to December 2013,al these case were treated with docetaxel-containing regimen first time, 47 patients with DCF regimen(DTX75mg/㎡,iv,d1,DDP20mg/㎡,iv,d1~d3,5-FU400 mg/㎡iv,d1~d5,LV300mg,iv,d1~d5,q3w),72patients with DC regimen(DTX75mg/㎡,iv,d1,DDP20mg/㎡,iv,d1~d3).The ef icacy and the toxicity were evaluated after two cycles. Results Al the cases could be evaluated ef icacy and toxicity, There was no statistical significance about the recent Response rate(RR) and the disease control rate (DCR) between the two groups, Toxicity of two groups were tolerable ,For the 3~4 degree toxicity, There was no statistical significance about neurotoxin and muscular pain. While the incidence rate of leucopenia, Nausea, vomit, weak, Diar hea were lower in DC regimen group than in DCF regimen group with significance dif erence. Conclusion The treatment of patients with advanced gastric cancer, DC regimen group and DCF regimen group had the similar ef ect, but the doublet regimen group had bet er tolerance, lower toxicity.