中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2014年
34期
51-51,53
,共2页
糖尿病酮症酸中毒%白细胞介素-6%肿瘤坏死因子-α%C反应蛋白
糖尿病酮癥痠中毒%白細胞介素-6%腫瘤壞死因子-α%C反應蛋白
당뇨병동증산중독%백세포개소-6%종류배사인자-α%C반응단백
Diabetes ketoacidosis%Interleukin-6%Tumor necrosis factor-α%C-reactive protein
目的:探讨糖尿病酮症酸中毒患者血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平变化与病情加重的关系。方法选取46例糖尿病酮症酸中毒患者,其中合并感染者28例,非感染者18例,同时选取同期非酮症糖尿病患者32例作为对照组。留取清晨空腹静脉血,检查血常规同时检测各组患者空腹血糖(FPG)、糖化血红蛋白(HbA1c)生化指标的变化情况;收集患者尿液检测尿酮体变化;ELISA法检测血清IL-6,TNF-α,CRP水平。结果DKA感染组和非感染组血清IL-6、TNF-α、CRP水平均明显高于对照组,差异具有统计学意义(均P<0.05)。与DKA非感染组相比,DKA感染组IL-6、TNF-α、CRP水平也有明显升高,差异也具有统计学意义(P<0.05)。DKA合并感染患者空腹血糖与IL-6、TNF-α、CRP均成正相关(r分别为0.534、0.652、0.493,均P<0.01),而DKA合并感染患者CRP与IL-6、TNF-α亦成正相关(r分别为0.678、0.624,均P<0.01)。结论糖尿病酮症酸中毒患者的血清IL-6、TNF-α、CRP水平变化明显升高,与疾病严重程度有一定的关系。
目的:探討糖尿病酮癥痠中毒患者血清白細胞介素-6(IL-6)、腫瘤壞死因子-α(TNF-α)、C反應蛋白(CRP)水平變化與病情加重的關繫。方法選取46例糖尿病酮癥痠中毒患者,其中閤併感染者28例,非感染者18例,同時選取同期非酮癥糖尿病患者32例作為對照組。留取清晨空腹靜脈血,檢查血常規同時檢測各組患者空腹血糖(FPG)、糖化血紅蛋白(HbA1c)生化指標的變化情況;收集患者尿液檢測尿酮體變化;ELISA法檢測血清IL-6,TNF-α,CRP水平。結果DKA感染組和非感染組血清IL-6、TNF-α、CRP水平均明顯高于對照組,差異具有統計學意義(均P<0.05)。與DKA非感染組相比,DKA感染組IL-6、TNF-α、CRP水平也有明顯升高,差異也具有統計學意義(P<0.05)。DKA閤併感染患者空腹血糖與IL-6、TNF-α、CRP均成正相關(r分彆為0.534、0.652、0.493,均P<0.01),而DKA閤併感染患者CRP與IL-6、TNF-α亦成正相關(r分彆為0.678、0.624,均P<0.01)。結論糖尿病酮癥痠中毒患者的血清IL-6、TNF-α、CRP水平變化明顯升高,與疾病嚴重程度有一定的關繫。
목적:탐토당뇨병동증산중독환자혈청백세포개소-6(IL-6)、종류배사인자-α(TNF-α)、C반응단백(CRP)수평변화여병정가중적관계。방법선취46례당뇨병동증산중독환자,기중합병감염자28례,비감염자18례,동시선취동기비동증당뇨병환자32례작위대조조。류취청신공복정맥혈,검사혈상규동시검측각조환자공복혈당(FPG)、당화혈홍단백(HbA1c)생화지표적변화정황;수집환자뇨액검측뇨동체변화;ELISA법검측혈청IL-6,TNF-α,CRP수평。결과DKA감염조화비감염조혈청IL-6、TNF-α、CRP수평균명현고우대조조,차이구유통계학의의(균P<0.05)。여DKA비감염조상비,DKA감염조IL-6、TNF-α、CRP수평야유명현승고,차이야구유통계학의의(P<0.05)。DKA합병감염환자공복혈당여IL-6、TNF-α、CRP균성정상관(r분별위0.534、0.652、0.493,균P<0.01),이DKA합병감염환자CRP여IL-6、TNF-α역성정상관(r분별위0.678、0.624,균P<0.01)。결론당뇨병동증산중독환자적혈청IL-6、TNF-α、CRP수평변화명현승고,여질병엄중정도유일정적관계。
?Objective?To?investigate?the?relationship?between?the?changes?of?serum?interleukin-6?(IL-6),?tumor?necrosis?factor-α?(TNF-α)?and?C-reactive?protein?(CRP)?levels?and?exacerbations?in?patients?with?diabetes?ketoacidosis.?Methods?46?patients?with?diabetes?ketoacidosis?were?recruited,?of?which?28?patients?were?infectious.?Besides,?32?diabetic?patients?without?diabetes?ketoacidosis?were?enrolled?as?control?at?the?same?time.?Routine?blood?test,?Fasting?blood?glucose?(FPG),?glycosylated?hemoglobin?(HbA1c)?and?urine?acetone?bodies?were?detected.?Serum?IL-6,?TNF-α,?and?CRP?was?measured?by?ELISA?kits.?Results?The?levels?of?IL-6,?TNF-α,?CRP?were?significantly?higher?in?both?DKA?groups?than?those?of?control?group?(P<0.05),?and?those?indexes?in?infectious?DKA?group?were?also?higher?compared?to?non-infectious?DKA?group?(P<0.05).?According?to?the?correlation?analysis,?there?was?a?positive?correlation?of?FPG,?IL-6,?TNF-α,?CRP(r=0.534,?0.652,?0.493,?all?P<0.01)?in?infectious?DKA?group.?Meanwhile,?CRP?had?a?correlation?with?IL-6?and?TNF-α?in?infectious?DKA?group?(r=0.678?and?0.624,?respectively,?all?P<0.01).?Conclusion?An?increase?of?CRP,?IL-6?and?CRP?in?DKA?were?detected?in?DKA?patients,?which?reflected?the?severity?of?DKA?to?some?extent.