CAJ | 학술논문

目的：观察探讨重组人干扰素α2b阴道泡腾胶囊治疗宫颈HPV感染的临床应用效果及安全性。方法随机抽取2013年3月至2014年3月在本院就诊的86例宫颈高危型HPVDNA检测阳性患者作为本次研究的对象，将86例患者随机分为治疗组和对照组，每组各43例。对照组患者不使用干扰素进行治疗。治疗组给予患者重组人干扰素α2b阴道泡腾胶囊进行治疗，嘱咐患者每晚进行外阴的清洁，随后将胶囊置于阴道后穹窿处，每天1次，每次1粒，10d为1个疗程，连续使用3个疗程，避开月经期。观察并比较两组患者治疗HPV感染的有效率、感染率和不良反应的情况。结果两组患者中HPV感染者大多数为高危亚型的感染者，高危亚型感染、再次感染和混合感染三种感染方式之间并不具有显著的差异(P＞0.05）。在3个月、6个月和9个月三次感染率的复查中两组数据均具有显著差异(P＜0.05），而在12个月后复查中，感染率并不具有显著的差异(P＞0.05）。结论应用重组人干扰素α2b阴道泡腾胶囊进行宫颈HPV感染的局部治疗，临床效果显著，是治疗宫颈HPV感染的有效且安全方便的方法，具有推广应用的价值。
목적：관찰탐토중조인간우소α2b음도포등효낭치료궁경HPV감염적림상응용효과급안전성。방법수궤추취2013년3월지2014년3월재본원취진적86례궁경고위형HPVDNA검측양성환자작위본차연구적대상，장86례환자수궤분위치료조화대조조，매조각43례。대조조환자불사용간우소진행치료。치료조급여환자중조인간우소α2b음도포등효낭진행치료，촉부환자매만진행외음적청길，수후장효낭치우음도후궁륭처，매천1차，매차1립，10d위1개료정，련속사용3개료정，피개월경기。관찰병비교량조환자치료HPV감염적유효솔、감염솔화불량반응적정황。결과량조환자중HPV감염자대다수위고위아형적감염자，고위아형감염、재차감염화혼합감염삼충감염방식지간병불구유현저적차이(P＞0.05）。재3개월、6개월화9개월삼차감염솔적복사중량조수거균구유현저차이(P＜0.05），이재12개월후복사중，감염솔병불구유현저적차이(P＞0.05）。결론응용중조인간우소α2b음도포등효낭진행궁경HPV감염적국부치료，림상효과현저，시치료궁경HPV감염적유효차안전방편적방법，구유추엄응용적개치。
Objective?To?observe?and?discuss?the?clinical?results?and?safety?observation?of?recombinant?human?interferon?α2b?vaginal?effervescent?capsule?treatment?of?cervical?HPV?infection.?Methods?86?cases?of?cervical?high-risk?HPV?DNA?testing?positive?patients?were?randomly?selected?as?the?object?of?this?study,?in?March?2013-March?2014?in?our?hospital,.the?86?patients?were?randomly?divided?into?treatment?group?and?control?group?with?43?people?each.?The?control?group?of?patients?not?treated?with?interferon.The?patients?of?treatment?group?were?received?recombinant?human?interferon?α2b?vaginal?effervescent?capsules?as?treatment,?the?patients?were?asked?to?clean?the?vulva?every?night,?then?put?the?capsule?in?the?vaginal?fornix,?once?a?day,?every?one,?10?days?for?a?course?of?treatment,?use?it?three?courses?continuously,?avoid?the?menstrual?period.?To?observe?and?compare?the?two?groups?of?treated?patients?with?HPV?infection?efficiency?of?infection?and?adverse?conditions.?Results?The?patients?of?two?groups?mostly?infected?with?the??high-risk?HPV?subtype?infection.?There?is?no?a?significant?difference?(P>0.05)between?the?high-risk?subtypes?of?infection,?re-infection?and?mixed?infection?between?three?kinds?of?Infection.?There?were?significant?differences?(P<0.05)between?three?months,?six?months?and?nine?months?to?review?the?prevalence?of?three?sets?of?data,?while?in?the?12?months?after?the?review,?the?rate?of?infection?was?not?a?significant?difference?(P>0.05).?Conclusion?The?application?of?recombinant?human?interferon?α2b?vaginal?effervescent?capsules?for?local?treatment?of?cervical?HPV?infection,?the?clinical?effect?is?significant,it?is?effective?and?safe?and?convenient?method?for?the?treatment?of?cervical?HPV?infection,?promote?the?use?of?value.