CAJ | 학술논문

目的：采用Meta分析方法研究高温茶水对人群食管癌患病风险的影响。方法：以茶、温度和食管癌为主题词及关键词，联合检索1966-2014年4月Medline、Pubmed、Embase、Cochrane数据库发表的相关文献。使用STATA 12.0软件进行效应值的合并和异质性检验，通过漏斗图、Begg和Egger回归计算发表偏倚。结果：本次研究共纳入9篇文献，包括3261名食管癌病例。通过比较饮用高温茶水组和饮用非高温茶水组食管癌的患病风险，高温茶水能够使食管癌患病风险增高(合并OR=2.21，95%CI 1.95~2.51，Z=12.50，P<0.00001)，通过Begg’s轶相关检验法得出Pr>|Z|=0.858>0.05；Egger’s回归法得出P=0.74>0.05，说明纳入文献发表偏倚较小。结论：高温茶水可能会增加人群食管癌的患病风险，但目前研究证据还比较有限。
목적：채용Meta분석방법연구고온다수대인군식관암환병풍험적영향。방법：이다、온도화식관암위주제사급관건사，연합검색1966-2014년4월Medline、Pubmed、Embase、Cochrane수거고발표적상관문헌。사용STATA 12.0연건진행효응치적합병화이질성검험，통과루두도、Begg화Egger회귀계산발표편의。결과：본차연구공납입9편문헌，포괄3261명식관암병례。통과비교음용고온다수조화음용비고온다수조식관암적환병풍험，고온다수능구사식관암환병풍험증고(합병OR=2.21，95%CI 1.95~2.51，Z=12.50，P<0.00001)，통과Begg’s질상관검험법득출Pr>|Z|=0.858>0.05；Egger’s회귀법득출P=0.74>0.05，설명납입문헌발표편의교소。결론：고온다수가능회증가인군식관암적환병풍험，단목전연구증거환비교유한。
Objective:To explore the correlation between hot tea drinking and risk of Esophageal cancer through Meta-analysis.Method:Relative studies published between 1966 to April 2014 about tea and risk of esophageal cancer were searched in Pubmed,Embase,Cochrane Data.The merging effect value and homogeneity were analyzed by using STATA 12.0 software,and the funnel plot,Begg’s and Egger’s test were adopted to examine the potential publication bias. Result:A total of 9 publications with 3261 esophageal cancer cases were included.Based on the comparison between the hot tea drinking group and not-hot tea drinking group,hot tea drinking was significantly increased the esophageal cancer risk(OR=2.21,95%CI 1.95-2.51,Z=12.50,P<0.000 01).There was no publication bias in these literatures by Begg’s test(Pr>|Z|=0.858>0.05) and Egger’s test(P=0.74>0.05).Conclusion:Hot tea drinking may increase the risk of esophageal cancer.