CAJ | 학술논문

目的：探究瑞舒伐他汀对冠心病患者超敏 C 反应蛋白（hs - CRP）及血脂的影响。方法选取我院2011年9月—2012年9月收治的142例冠心病患者作为研究对象，将其随机分为观察组和对照组，各71例。对照组患者给予阿托伐他汀治疗，观察组患者给予瑞舒伐他汀治疗。比较两组患者治疗前后hs - CRP、血脂〔总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL - C）、高密度脂蛋白胆固醇（HDL - C）〕及治疗过程中不良反应情况。结果治疗前后两组患者hs - CRP、TC、TG、LDL - C 以及 HDL - C 比较，差异有统计学意义（P 〈0.05）；治疗后观察组患者hs - CRP、TC、TG、LDL - C 低于对照组，HDL - C 高于对照组，差异有统计学意义（P 〈0.05）。两组患者不良反应发生率比较，差异无统计学意义（ P 〉0.05）。结论瑞舒伐他汀能够改善冠心病患者炎性反应和血脂，有助于延缓动脉粥样硬化进程，且不良反应较少。
목적：탐구서서벌타정대관심병환자초민 C 반응단백（hs - CRP）급혈지적영향。방법선취아원2011년9월—2012년9월수치적142례관심병환자작위연구대상，장기수궤분위관찰조화대조조，각71례。대조조환자급여아탁벌타정치료，관찰조환자급여서서벌타정치료。비교량조환자치료전후hs - CRP、혈지〔총담고순（TC）、삼선감유（TG）、저밀도지단백담고순（LDL - C）、고밀도지단백담고순（HDL - C）〕급치료과정중불량반응정황。결과치료전후량조환자hs - CRP、TC、TG、LDL - C 이급 HDL - C 비교，차이유통계학의의（P 〈0.05）；치료후관찰조환자hs - CRP、TC、TG、LDL - C 저우대조조，HDL - C 고우대조조，차이유통계학의의（P 〈0.05）。량조환자불량반응발생솔비교，차이무통계학의의（ P 〉0.05）。결론서서벌타정능구개선관심병환자염성반응화혈지，유조우연완동맥죽양경화진정，차불량반응교소。
Objective To study the impact of rosuvastatin on hs - CRP and blood liquid of patients with coronary heart disease. Methods A total of 142 patients with coronary heart disease were chosen in our hospital from September 2011 to September 2012,and they were randomly divided into observation group and control group,71 cases in each group. Control group given atorvastatin,while observation group given rosuvastatin. Before and after treatment,hs - CRP,total cholesterol (TC),triglyceride(TG),low density lipoprotein cholesterol(LDL - C),high - density lipoprotein cholesterol(HDL - C) of the two groups were compared,and incidence of adverse reactions during treatment observed. Results There were statistical-ly significant differences of hs - CRP,TC,TG,LDL - C and HDL - C of the two groups before and after treatment( P 〈0. 05),and hs - CRP,TC,TG,LDL - C of observation group were lower than those of control group after treatment,HDL -C was higher,the differences were statistically significantly different(P 〈 0. 05). There was no statistically significant differ-ence of incidence of adverse reactions between the two groups during treatment. Conclusion Rosuvastatin can significantly im-prove inflammation and blood lipid of patients with coronary heart disease,which is helpful to delay the process of atherosclero-sis,and is with less adverse reactions.