CAJ | 학술논문

目的探讨枯草杆菌二联活菌肠溶胶囊联合美沙拉嗪治疗轻、中度溃疡性结肠炎的临床疗效。方法采用回顾性分析方法，随机选取武汉市中心医院2010年1月~2013年12月收治的36例采用枯草杆菌二联活菌肠溶胶囊联合美沙拉嗪治疗和36例采用美沙拉嗪治疗的轻、中度活动期溃疡性结肠炎患者的临床资料进行分析，根据治疗方法的不同分为联合组和对照组。比较两组在治疗8 w时间后的临床疗效和不良反应情况。结果治疗8 w后联合组总有效率为91.67豫，对照组为63.89豫；不良反应联合组发生2例，对照组发生12例；两组临床效果和不良反应发生情况对比差异均有统计学意义(<0.05)。结论枯草杆菌二联活菌肠溶胶囊联合美沙拉嗪治疗轻、中度活动期溃疡性结肠炎可提高临床疗效并减少不良反应发生。
목적탐토고초간균이련활균장용효낭연합미사랍진치료경、중도궤양성결장염적림상료효。방법채용회고성분석방법，수궤선취무한시중심의원2010년1월~2013년12월수치적36례채용고초간균이련활균장용효낭연합미사랍진치료화36례채용미사랍진치료적경、중도활동기궤양성결장염환자적림상자료진행분석，근거치료방법적불동분위연합조화대조조。비교량조재치료8 w시간후적림상료효화불량반응정황。결과치료8 w후연합조총유효솔위91.67예，대조조위63.89예；불량반응연합조발생2례，대조조발생12례；량조림상효과화불량반응발생정황대비차이균유통계학의의(<0.05)。결론고초간균이련활균장용효낭연합미사랍진치료경、중도활동기궤양성결장염가제고림상료효병감소불량반응발생。
Objective To evaluate the clinical ef ect of Medilac-S (live combined Bacil us subtilis and Enterococcus faecium enteric-coated capsules)combined with mesalazine in the treatment of mild to moderate ulcerative colitis patients.Methods Take retrospective analysis method to analyse clinical data of 36 patients with mild to moderate ulcerative colitis using Medilac-S combined with mesalazine treatment and 36 with mesalazine method which randomly selected from January 2010 to December 2013.Divided into control group and combination group according to the dif erent method of treatment and compared.The clinical ef icacy and adverse reactions of the two groups were observed after 8 weeks of treatment.Results After 8 weeks,the total ef ective rate of clinical outcomes in the combination group and the control group was 91.67%and 63.89%;Adverse reactions occur ed 2 cases of the combination group and 12 cases in the control group.The dif erence was statistical y significant ( <0.05).Conclusion The combination of Medilac-S and mesalazine in the treatment of mild to moderate ulcerative colitis could significantly raise the clinical ef icacy and reduce the incidence of adverse reactions.