光谱学与光谱分析
光譜學與光譜分析
광보학여광보분석
SPECTROSCOPY AND SPECTRAL ANALYSIS
2015年
1期
137-140
,共4页
Rizatriptan benzoate%UV spectroscopy%Stress degradation%Validation
Rizatriptan benzoate is a 5 HT 1B/1D receptor agonist which is prescribed for the treatment of mi-graine .In the present study new ,simple ,specific ultraviolet spectrophotometric method for rizatriptan benzo-ate was developed and validated .Forced degradation studies were carried out in acidic ,alkaline and neutral pH conditions .The absorbance maxima peak was found to be 224 nm and linearity was observed in the concentra-tion range of 0.5~2.5 μg?mL -1 with regression coefficient value of 0.998 8 .The method was validated and found to be precise .The percent recovery for rizatriptan benzoate was found to be 98.576 ± 0.202 .The bulk drug was found to be stable in neutral and acidic pH conditions but got degraded in 1 N NaOH solution .
