CAJ | 학술논문

目的：探讨艾司西酞普兰治疗癫痫患者并发抑郁的疗效及安全性。方法84例健康问卷抑郁量表（ patient health questionnaire 9-item depression scale，PHQ-9）评分≥15分的成年癫痫并发抑郁患者，按随机数字表法分为观察组（n＝43）和对照组（n＝41），两组均给予常规抗癫痫药物治疗，治疗组在此基础上，给予艾司西酞普兰（10 mg／d）抗抑郁治疗。比较两组治疗前、治疗3月后癲痫发作频率及PHQ-9评分等。结果观察组和对照组分别有41例和40例完成试验。治疗3月后，两组患者PHQ-9评分及癫痫发作频率均较治疗前显著降低（均P ＜0.05），观察组患者PHQ-9评分及癫痫发作频率降低较对照组更显著（均P＜0.05）。两组患者不良反应差异无统计学意义（ P＞0.05）。结论艾司西酞普兰可以明显改善癫痫患者的抑郁症状，与抗癫痫药物联合应用，可使癫痫发作次数减少，且安全性好。
목적：탐토애사서태보란치료전간환자병발억욱적료효급안전성。방법84례건강문권억욱량표（ patient health questionnaire 9-item depression scale，PHQ-9）평분≥15분적성년전간병발억욱환자，안수궤수자표법분위관찰조（n＝43）화대조조（n＝41），량조균급여상규항전간약물치료，치료조재차기출상，급여애사서태보란（10 mg／d）항억욱치료。비교량조치료전、치료3월후전간발작빈솔급PHQ-9평분등。결과관찰조화대조조분별유41례화40례완성시험。치료3월후，량조환자PHQ-9평분급전간발작빈솔균교치료전현저강저（균P ＜0.05），관찰조환자PHQ-9평분급전간발작빈솔강저교대조조경현저（균P＜0.05）。량조환자불량반응차이무통계학의의（ P＞0.05）。결론애사서태보란가이명현개선전간환자적억욱증상，여항전간약물연합응용，가사전간발작차수감소，차안전성호。
Objective To assess the efficacy and safety of escitalopram in the treatment of adult epileptic patients complicated with depression.Methods Eighty-four adult epileptic patients whose score of PHQ-9 was more than 15 were randomly divided into study group(n =43)and control group(n =41).In the study group,patients were treated with escitalopram(10 mg/d)and AEDs while patients were treated with AEDs only in the control group.The monthly seizure frequency and depression severity were investigated before and after 12 weeks of the treatment.Results Forty-one patients in the study group and 40 patients in the control group had com-pleted the observation.The PHQ-9 scores and monthly seizure frequency were significantly decreased in the both groups when compared to before treatment(P<0.05).The improvements in the study groups were better than that in the control group(P<0.05)while there was no significant difference in adverse reaction between the two groups.Conclusion Escitalopram can obviously improve the depres-sion of epileptic patients.Combination of the drug with antiepileptic drugs can also reduce the seizure frequency with a good safety.