CAJ | 학술논문

目的：探讨多脏器功能障碍综合征（multiple organ dysfunction syndrome MODS）患者连续性血液滤过治疗肝素许可用量与预后的相关性分析。方法选择我院 MODS 行连续性血液滤过治疗患者60例，依据预后分为死亡组和存活组。评估肝素许可用量与病情危重程度及预后的相关性。结果①肝素的平均许可用量（8．27±1．19） U·kg－1·h－1。死亡组肝素的许可用量明显少于存活组，（6．55±1．48）U·kg－1·h－1 vs （9．59±0．96）U·kg－1· h－1（P ＜0．05）。②肝素的许可用量与年龄、APACHEⅡ评分呈明显负相关（r ＝－0．550，－0．563，P ＜0．01）。结论 MODS 患者连续性血液滤过治疗中肝素的许可用量与 MODS 患者的预后密切相关。
목적：탐토다장기공능장애종합정（multiple organ dysfunction syndrome MODS）환자련속성혈액려과치료간소허가용량여예후적상관성분석。방법선택아원 MODS 행련속성혈액려과치료환자60례，의거예후분위사망조화존활조。평고간소허가용량여병정위중정도급예후적상관성。결과①간소적평균허가용량（8．27±1．19） U·kg－1·h－1。사망조간소적허가용량명현소우존활조，（6．55±1．48）U·kg－1·h－1 vs （9．59±0．96）U·kg－1· h－1（P ＜0．05）。②간소적허가용량여년령、APACHEⅡ평분정명현부상관（r ＝－0．550，－0．563，P ＜0．01）。결론 MODS 환자련속성혈액려과치료중간소적허가용량여 MODS 환자적예후밀절상관。
ABSTRACT:Objective To investigate the relationship between permissible dose of heparin and the severity of illness and the prognosis of the patients with multiple organ dysfunction syndrome(MODS)during continuous veno-venous hemofiltration(CVVH).Methods Sixty patients with MODS undergoing CVVH in our hospital were divided into death group and survival group according to their prognosis.The relationship between the permissible dose of heparin and the severity of illness and the prognosis of the patients were assessed.Results The mean permissible dose of heparin in the death group was significantly less than that in the survival group (6.55±1.48 U·kg-1 ·h-1 vs 9.59±0.96 U·kg-1 ·h-1 ,P <0.05).Moreover,the permissible dose of heparin had significantly negative correlation with ages and APACHE Ⅱ scores of the patients (r = -0.550,-0.563,respectively;P < 0.01 ).Conclusion The permissible dose of heparin is closely correlated with the prognosis of the patients with MODS.