CAJ | 학술논문

目的：探讨孟鲁司特联合沙丁胺醇气雾剂治疗咳嗽变异性哮喘的临床疗效。方法选取128例咳嗽变异性哮喘患者，随机分为观察组和对照组，对照组仅给予沙丁胺醇气雾剂，观察组采用孟鲁司特联合沙丁胺醇气雾剂治疗，比较两组患者临床疗效、肺功能、咳嗽消失时间及血清细胞因子变化。结果对照组治疗有效率为75．0％，观察组有效率为94．8％，观察组显著优于对照组（P ＜0．05）。观察组第1秒用力呼气容积（FEV1）、第1秒用力呼气容积／用力肺活量（FEV1／FVC）分别为（2．19±0．16）L、（66．09±4．34）％，对照组 FEV1、FEV1／FVC 分别为（1．83±0．12） L、（52．15±3．41）％，两组比较差异有统计学意义（t ＝3．131、4．850，P ＝0．035、0．008，P ＜0．05）。观察组血清白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）分别为（14．06±2．94）ng／L、（0．68±0．11）ng／L，对照组血清 IL-6、TNF-α分别为（20．91±3．08）ng／L、（0．99±0．13）ng／L，两组比较差异有统计学意义（P ＜0．05）。对照组患者平均咳嗽消失时间为（6．33±0．58）d，观察组患者平均咳嗽消失时间为（9．33±0．58）d，两组比较差异有统计学意义（P ＜0．01或＜0．05）。结论采用孟鲁司特联合沙丁胺醇气雾剂在治疗咳嗽变异性哮喘安全有效，值得临床推广使用。
목적：탐토맹로사특연합사정알순기무제치료해수변이성효천적림상료효。방법선취128례해수변이성효천환자，수궤분위관찰조화대조조，대조조부급여사정알순기무제，관찰조채용맹로사특연합사정알순기무제치료，비교량조환자림상료효、폐공능、해수소실시간급혈청세포인자변화。결과대조조치료유효솔위75．0％，관찰조유효솔위94．8％，관찰조현저우우대조조（P ＜0．05）。관찰조제1초용력호기용적（FEV1）、제1초용력호기용적／용력폐활량（FEV1／FVC）분별위（2．19±0．16）L、（66．09±4．34）％，대조조 FEV1、FEV1／FVC 분별위（1．83±0．12） L、（52．15±3．41）％，량조비교차이유통계학의의（t ＝3．131、4．850，P ＝0．035、0．008，P ＜0．05）。관찰조혈청백세포개소6（IL-6）、종류배사인자α（TNF-α）분별위（14．06±2．94）ng／L、（0．68±0．11）ng／L，대조조혈청 IL-6、TNF-α분별위（20．91±3．08）ng／L、（0．99±0．13）ng／L，량조비교차이유통계학의의（P ＜0．05）。대조조환자평균해수소실시간위（6．33±0．58）d，관찰조환자평균해수소실시간위（9．33±0．58）d，량조비교차이유통계학의의（P ＜0．01혹＜0．05）。결론채용맹로사특연합사정알순기무제재치료해수변이성효천안전유효，치득림상추엄사용。
ABSTRACT:Objective To evaluate the clinical efficacy of montelukast combined with salbutamol aerosol treatment in cough variant asthma.Methods A total of 128 patients with cough variant asthma were randomly divided into control group and observation group,64 cases in each group.Montelukast combined with salbutamol aerosol were used in observation group and salbutamol aerosol alone was used in control group.The clinical efficacy,lung function, cough disappeared time and the changes of serum cytokines were compared between two groups.Results The efficiency of observation group was 94.8%,as compared with that of control group 75.0%,the difference was statistically significant (P <0.05).The FEV1 and FEV1/FVC of observation group were respectively (2.19±0.16) L and (66.09±4.34)%,those of control group (1.83±0.12)L and (52.15±3.41)%,showed significant differences between the two groups(both P < 0.05).The serum interleukin-6 (IL-6)and tumor necrosis factor-α(TNF-α)of observation group were (14.06±2.94)ng/L and (0.68±0.11)ng/L,those of control group (20.91±3.08)ng/L and (0.99±0.13)ng/L,showed significant differences between two groups (both P <0.05).The cough disappeared time of observation group was (9.33 ± 0.58)d,that of control group (6.33 ± 0.58)d,showed significant differences between the two groups(P <0.01).Conclusion Montelukast combined with salbutamol aerosol treatment in cough variant asthma is safe and effective,worths clinical promotion.