CAJ | 학술논문

目的：观察乙酰半胱氨酸联合泼尼松治疗特发性肺间质纤维化（IPF）患者的治疗效果。方法将45例IPF 患者随机分为3组，泼尼松组15例（A 组），每日（理想体质量）0．5 mg／kg，口服4周，然后每日0．25 mg／kg，口服8周，继之减量至每日0．125 mg／kg 口服；小剂量乙酰半胱氨酸组15例（B 组），在上述泼尼松治疗基础上加用乙酰半胱氨酸200 mg，每日3次；大剂量乙酰半胱氨酸组15例（C 组），在上述泼尼松治疗基础上加用大剂量乙酰半胱氨酸600 mg，每日3次；疗程6个月。观察治疗前后各组患者肺活量（VC）、6分钟步行试验（6MWT）距离变化，评价总体疗效。结果3组治疗后 VC、6MWT 较治疗前均降低。C 组疗效好于 A 组和 B 组（P ＜0．05）。C 组 VC、6MWT 较其他治疗组下降缓慢（P ＜0．05）。结论大剂量乙酰半胱氨酸联合泼尼松能延缓特发性肺间质纤维化患者肺功能下降及6MWT 距离的减少。
목적：관찰을선반광안산연합발니송치료특발성폐간질섬유화（IPF）환자적치료효과。방법장45례IPF 환자수궤분위3조，발니송조15례（A 조），매일（이상체질량）0．5 mg／kg，구복4주，연후매일0．25 mg／kg，구복8주，계지감량지매일0．125 mg／kg 구복；소제량을선반광안산조15례（B 조），재상술발니송치료기출상가용을선반광안산200 mg，매일3차；대제량을선반광안산조15례（C 조），재상술발니송치료기출상가용대제량을선반광안산600 mg，매일3차；료정6개월。관찰치료전후각조환자폐활량（VC）、6분종보행시험（6MWT）거리변화，평개총체료효。결과3조치료후 VC、6MWT 교치료전균강저。C 조료효호우 A 조화 B 조（P ＜0．05）。C 조 VC、6MWT 교기타치료조하강완만（P ＜0．05）。결론대제량을선반광안산연합발니송능연완특발성폐간질섬유화환자폐공능하강급6MWT 거리적감소。
ABSTRACT:Objective To study the effects of acetylcysteine plus prednisone on idiopathic pulmonary fibrosis (IPF)patients.Methods Forty-five IPF patients were randomly divided into control group 15 cases (treated with prednisone therapy only,group A),low doses of acetylcysteine plus prednisone group 15 cases (acetylcysteine 200 mg per time,3 times a day orally for 6 months,group B)and large doses of acetylcysteine plus prednisone group 15 cases (acetylcysteine 600 mg per time,3 times a day orally for 6 months,group C).The change of clinical symptoms,vital capacity(VC),6 minute walk test distance(6MWT)were observed.Results VC and 6MWT after treatment were significantly lower than before treatment in all three groups.The effects in group C were significantly better than those in group A and B(P <0.05).Conclusion High dose acetylcysteine plus prednisone therapy delayed IPF in patients with reduced lung function and decreased in 6 MWT.