CAJ | 학술논문

采用微流控乳化和紫外光照引发制备聚（N-异丙基丙烯酰胺-共聚-丙烯酸）微囊，然后通过缩合反应将氨基化β-环糊精（ECD）引入微囊成功制备得到聚（N-异丙基丙烯酰胺-共聚-丙烯酸/氨基化β-环糊精）（PNA-ECD）微囊。PNA-ECD 微囊具有明显的核壳型结构和良好的单分散性。微囊的平均直径为470μm，CV 值为2.98%。PNA-ECD微囊在识别模型芳环分子8-苯胺-1-萘磺酸铵盐（ANS）后能等温收缩从而实现对内载药物的控制释放。32℃时，微囊内部的模型药物异硫氰酸荧光素标记葡聚糖（FITC-dextran）在纯水中无明显释放，而在加入2.0mmol/L ANS溶液16min后，微囊内部约70%的FITC-dextran释放到微囊外部。研究结果对制备单分散分子识别型智能微囊及研究其控制释放特性提供有价值的理论指导和实验基础。
채용미류공유화화자외광조인발제비취（N-이병기병희선알-공취-병희산）미낭，연후통과축합반응장안기화β-배호정（ECD）인입미낭성공제비득도취（N-이병기병희선알-공취-병희산/안기화β-배호정）（PNA-ECD）미낭。PNA-ECD 미낭구유명현적핵각형결구화량호적단분산성。미낭적평균직경위470μm，CV 치위2.98%。PNA-ECD미낭재식별모형방배분자8-분알-1-내광산안염（ANS）후능등온수축종이실현대내재약물적공제석방。32℃시，미낭내부적모형약물이류청산형광소표기포취당（FITC-dextran）재순수중무명현석방，이재가입2.0mmol/L ANS용액16min후，미낭내부약70%적FITC-dextran석방도미낭외부。연구결과대제비단분산분자식별형지능미낭급연구기공제석방특성제공유개치적이론지도화실험기출。
Poly(N-isopropylacrylamide-co-acrylic acid/aminated β-cyclodextrin) (PNA-ECD) microcapsules were fabricated by the condensation reaction between aminated β-cyclodextrin and poly(N-isopropylacrylamide-co-acrylic acid) microcapsules. The poly(N-isopropylacrylamide-co-acrylic acid) microcapsules were prepared by initiating polymerization of multiple emulsion containing N-isopropylacrylamide and acrylic acid,which was generated by microfluidic emulsification. The PNA-ECD microcapsules showed core-shell structure and satisfactory monodispersity. Average outer diameter of microcapsules was 470 μm,and CV value was 2.98%. By recognizing model molecules 8-anilino-1-naphthalenesulfonic acid ammonium salt (ANS) , the PNA-ECD microcapsules isothermally shrunk and controllably released the encapsulated model drug molecule fluorescein isothiocyanate labeled dextran (FITC-dextran). At 32℃,there was no obvious drug release for the PNA-ECD microcapsules in pure water,while about 70% of the encapsulated FITC-dextran was released from the microcapsules after adding ANS solution (2.0mmol/L) for 16min. The results provide valuable guidance for fabrication of monodisperse molecular-recognizable microcapsules and studying their molecular-recognizable characteristics.