CAJ | 학술논문

目的：建立深圳地区3月龄至18周岁健康人群干式化学法血清 K+、Na+、Cl_、总钙（ TCa ）、总二氧化碳（ TCO2）、空腹血糖（ FBG）的参考区间值。方法根据儿童青少年生长发育规律分为3月龄至3岁、~6岁、~12岁和~18岁组。标本来源为健康体检常规检测后的剩余标本。采用美国强生公司VITROS 350干式化学分析仪检测血清K+、Na+、Cl_、TCa、TCO2和FBG水平，比较不同年龄组和不同性别间的差异，并确定6项检测指标在3月龄至18岁健康人群中的参考区间值。结果1898名儿童青少年合格标本进入分析，其中男1033名，女865名。3月龄至3岁组163名，~6岁组791名，~12岁组613名，~18岁组331名。①各年龄组男童TCa检测结果均低于女童，~6岁组男童FBG检测结果高于女童，差异均有统计学意义（P均<0.05），其余各组不同性别间差异均无统计学意义（P均>0.05）。Na+、Cl_、TCa和FBG在同性别不同年龄组间差异均有统计学意义（ P均<0.05），K+和TCO2在同性别不同年龄组间差异均无统计学意义（P均>0.05）。②K+、Na+、Cl_、TCa、TCO2和FBG在3月龄至18岁健康人群中的参考区间值（P2.5~P97.5）分别为3.4~4.9、134~147、98~110、2.18~2.60、19~28和3.6~6.0 mmol·L_1。③空腹血糖受损（ IFG）总检出率为2.3%（男2.9%，女1.6%）。3月龄至3岁组未检出IFG，~6岁、~12岁和~18岁组IFG检出率分别为1.0%、3.4%和4.5%。各年龄组间IFG检出率差异均有统计学意义（P均<0.05），同一年龄组间男童IFG检出率均高于女童（P均<0.05）。结论以深圳地区3月龄至18岁健康儿童为人群的干式化学法血清K+、Na+、Cl_、TCa、TCO2和FBG的参考区间值在不同性别和年龄总体差别不大，与既往国内外相关研究差别不大。
목적：건립심수지구3월령지18주세건강인군간식화학법혈청 K+、Na+、Cl_、총개（ TCa ）、총이양화탄（ TCO2）、공복혈당（ FBG）적삼고구간치。방법근거인동청소년생장발육규률분위3월령지3세、~6세、~12세화~18세조。표본래원위건강체검상규검측후적잉여표본。채용미국강생공사VITROS 350간식화학분석의검측혈청K+、Na+、Cl_、TCa、TCO2화FBG수평，비교불동년령조화불동성별간적차이，병학정6항검측지표재3월령지18세건강인군중적삼고구간치。결과1898명인동청소년합격표본진입분석，기중남1033명，녀865명。3월령지3세조163명，~6세조791명，~12세조613명，~18세조331명。①각년령조남동TCa검측결과균저우녀동，~6세조남동FBG검측결과고우녀동，차이균유통계학의의（P균<0.05），기여각조불동성별간차이균무통계학의의（P균>0.05）。Na+、Cl_、TCa화FBG재동성별불동년령조간차이균유통계학의의（ P균<0.05），K+화TCO2재동성별불동년령조간차이균무통계학의의（P균>0.05）。②K+、Na+、Cl_、TCa、TCO2화FBG재3월령지18세건강인군중적삼고구간치（P2.5~P97.5）분별위3.4~4.9、134~147、98~110、2.18~2.60、19~28화3.6~6.0 mmol·L_1。③공복혈당수손（ IFG）총검출솔위2.3%（남2.9%，녀1.6%）。3월령지3세조미검출IFG，~6세、~12세화~18세조IFG검출솔분별위1.0%、3.4%화4.5%。각년령조간IFG검출솔차이균유통계학의의（P균<0.05），동일년령조간남동IFG검출솔균고우녀동（P균<0.05）。결론이심수지구3월령지18세건강인동위인군적간식화학법혈청K+、Na+、Cl_、TCa、TCO2화FBG적삼고구간치재불동성별화년령총체차별불대，여기왕국내외상관연구차별불대。
Objective To investigate the reference intervals of serum kalium ion( K+),natrium ion( Na+),chlorine ion ( Cl_),total calcium( TCa ),total carbon dioxide( TCO2 ) and fasting blood glucose( FBG ) among healthy children and adolescents( aged from 3 months to 18 years)by dry chemical system in Shenzhen. Methods Healthy children and adolescents were divided into four groups by age according to the rule of growth and development:3 months to 3 years,_6 years,_12 years and _18 years age groups. The serum was from the remaining specimens of routine physical examination after routine testing. Serum K+,Na+,Cl_,TCa,TCO2 and FBG were detected by the VITROS 350 system,and the differences between different age groups and different genders were compared and the reference intervals of 6 items among healthy children and adolescents aged from 3 months to 18 years were established. Results A total of 1 898 qualified specimens from children and adolescents were recruited, including 1 033 males and 865 females,with 163,791,613 and 331 subjects for 3 months to 3 years group,_6 years group,_12 years group and _18 years group. ①TCa in boys was significantly lower than that in girls,but FBG of _6 years group in boys was significantly higher than that in girls,there was no significant difference between genders in other groups(P>0. 05). Na+, Cl_,TCa and FBG significantly varied among age groups in each gender(P<0. 05),however K+and TCO2 did not(P>0. 05).②Reference intervals of serum K+,Na+,Cl_,TCa,TCO2 and FBG were 3. 4_4. 9,134_147,98_110,2. 18_2. 60,19_28,3. 6_6. 0 mmol·L_1 respectively. ③The overall detection rate of IFG was 2. 3%(2. 9% for male and 1. 6% for female). There was no detectale IFG in 3 months to 3 years group,the detection rate of IFG in _6 years,_12 years,_18 years groups was 1. 0%,3. 4% and 4. 5%,respectively,varying significantly among age groups(P<0. 05),being more common in boys than that in girls(P<0. 05). Conclusion Reference intervals of serum K+,Na+,Cl_,TCa,TCO2 and FBG are established by dry chemical system among healthy children and adolescents in Shenzhen. It has little difference in different ages,genders and previous studies of domestic and foreign.