中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2014年
6期
16-18
,共3页
章国晶%周立江%刘兆喆%徐龙%郭放%韩涛%苏冰%郭剑非%韩雅玲%谢晓冬
章國晶%週立江%劉兆喆%徐龍%郭放%韓濤%囌冰%郭劍非%韓雅玲%謝曉鼕
장국정%주립강%류조철%서룡%곽방%한도%소빙%곽검비%한아령%사효동
p53%三阴性乳腺癌%新辅助化疗%病理完全缓解
p53%三陰性乳腺癌%新輔助化療%病理完全緩解
p53%삼음성유선암%신보조화료%병리완전완해
p53%Triple-negative breast cancer%Neoadjuvant chemotherapy%Pathological complete response
目的：相关研究显示p53基因的表达情况可预测三阴性乳腺癌（TNBC）在新辅助化疗（NAC）中获得病理完全缓解（pCR）的概率，但各研究结果并不一致，尚无大样本研究给予可靠结论。方法检索PubMed寻找相关文献，提取各研究中p53高表达TNBC和p53低表达TNBC的总人数和获得pCR的人数，以优势比（OR）和95%置信区间（CI）评估p53的表达情况与各组pCR率之间的关系，应用Review Manager和MIX软件完成数据合并。结果共纳入4项研究，个体OR值波动于0.58～2.56之间，总体合并OR为1.03（95% CI：0.61～1.73），森林图中菱形与垂直线相交，文献之间无明显异质性，失安全系数计算结果为2，存在潜在发表偏倚。结论 p53的表达情况不能作为TNBC在NAC中获得pCR的预测因子。
目的：相關研究顯示p53基因的錶達情況可預測三陰性乳腺癌（TNBC）在新輔助化療（NAC）中穫得病理完全緩解（pCR）的概率，但各研究結果併不一緻，尚無大樣本研究給予可靠結論。方法檢索PubMed尋找相關文獻，提取各研究中p53高錶達TNBC和p53低錶達TNBC的總人數和穫得pCR的人數，以優勢比（OR）和95%置信區間（CI）評估p53的錶達情況與各組pCR率之間的關繫，應用Review Manager和MIX軟件完成數據閤併。結果共納入4項研究，箇體OR值波動于0.58～2.56之間，總體閤併OR為1.03（95% CI：0.61～1.73），森林圖中蔆形與垂直線相交，文獻之間無明顯異質性，失安全繫數計算結果為2，存在潛在髮錶偏倚。結論 p53的錶達情況不能作為TNBC在NAC中穫得pCR的預測因子。
목적：상관연구현시p53기인적표체정황가예측삼음성유선암（TNBC）재신보조화료（NAC）중획득병리완전완해（pCR）적개솔，단각연구결과병불일치，상무대양본연구급여가고결론。방법검색PubMed심조상관문헌，제취각연구중p53고표체TNBC화p53저표체TNBC적총인수화획득pCR적인수，이우세비（OR）화95%치신구간（CI）평고p53적표체정황여각조pCR솔지간적관계，응용Review Manager화MIX연건완성수거합병。결과공납입4항연구，개체OR치파동우0.58～2.56지간，총체합병OR위1.03（95% CI：0.61～1.73），삼림도중릉형여수직선상교，문헌지간무명현이질성，실안전계수계산결과위2，존재잠재발표편의。결론 p53적표체정황불능작위TNBC재NAC중획득pCR적예측인자。
ObjectiveSome published literatures showed p53 expression was a prognosis to pathological complete response(pCR) of neoadjuvant chemotherapy(NAC) in triple-negative breast cancer(TNBC) with some contrary results. The meta-analysis was conducted to estimate the predict function of p53 to pCR rates of NAC in TNBC.MethodsRelevant literatures were selected from January 2006 to July 2014 by searching the PubMed. The pCR rates of p53 high expression TNBC and p53 low expression TNBC were extracted. Odds ratio(OR) and 95% confidence interval(CI) were used to estimate prognostic function of p53 in pCR rates of TNBC. Review Manager and MIX software were used to merge extractive data. Results4 studies were selected in this analysis. ORs were from 0.58 to 2.56. The merged OR was 1.03(95%CI: 0.61~1.73) and the fail-safe number was 2. The diamond crossed perpendicular line in forest plot. No obvious statistical heterogeneity were detected. Publication bias was obviously.Conclusionp53 was not a predictor to pCR rates of NAC in TNBC.
