医学美学美容(中旬刊)
醫學美學美容(中旬刊)
의학미학미용(중순간)
MEDICAL AESTHETICS AND COSMETOLOGY
2014年
12期
43-43
,共1页
子痫前期%血管内皮生长因子%可溶性血管内皮生长因子受体l
子癇前期%血管內皮生長因子%可溶性血管內皮生長因子受體l
자간전기%혈관내피생장인자%가용성혈관내피생장인자수체l
Preeclampsia%VEGF%SFlt-1
目的:探讨子痫前期患者血清中血管内皮生长因子(VEGF)及其可溶性受体l(sFlt-1)的水平及意义。方法选择2011年8月至2012年3月在河北省沧州市中心医院产科分娩的子痫前期患者共60例(研究组),其中轻度子痫前期孕妇30例(轻度子痫前期组),重度子痫前期孕妇30例(重度子痫前期组),以同期正常晚期妊娠孕妇30例(对照组)。采用酶联免疫吸附试验法测定子痫前期患者孕晚期、临产前及产后血清VEGF及其sFlt-1水平,并与正常孕妇对照比较。结果两组在孕晚期及临产前的VEGF、sFlt-1水平比较,差异均有统计学意义(P<O.01)。轻度子痫前期与重度子痫前期患者在孕晚期及临产前的VEGF、sFlt-1水平比较,差异也均有统计学意义(P<0.01)。两组在产后的VEGF、sFlt-1水平比较差异均无统计学意义(P>0.05)。结论子痫前期患者血清中sFlt-1水平于孕晚期及临产前较正常孕妇明显增高,而VEGF水平降低,提示VEGF、sFlt-1可作为诊断子痫前期的指标之一。
目的:探討子癇前期患者血清中血管內皮生長因子(VEGF)及其可溶性受體l(sFlt-1)的水平及意義。方法選擇2011年8月至2012年3月在河北省滄州市中心醫院產科分娩的子癇前期患者共60例(研究組),其中輕度子癇前期孕婦30例(輕度子癇前期組),重度子癇前期孕婦30例(重度子癇前期組),以同期正常晚期妊娠孕婦30例(對照組)。採用酶聯免疫吸附試驗法測定子癇前期患者孕晚期、臨產前及產後血清VEGF及其sFlt-1水平,併與正常孕婦對照比較。結果兩組在孕晚期及臨產前的VEGF、sFlt-1水平比較,差異均有統計學意義(P<O.01)。輕度子癇前期與重度子癇前期患者在孕晚期及臨產前的VEGF、sFlt-1水平比較,差異也均有統計學意義(P<0.01)。兩組在產後的VEGF、sFlt-1水平比較差異均無統計學意義(P>0.05)。結論子癇前期患者血清中sFlt-1水平于孕晚期及臨產前較正常孕婦明顯增高,而VEGF水平降低,提示VEGF、sFlt-1可作為診斷子癇前期的指標之一。
목적:탐토자간전기환자혈청중혈관내피생장인자(VEGF)급기가용성수체l(sFlt-1)적수평급의의。방법선택2011년8월지2012년3월재하북성창주시중심의원산과분면적자간전기환자공60례(연구조),기중경도자간전기잉부30례(경도자간전기조),중도자간전기잉부30례(중도자간전기조),이동기정상만기임신잉부30례(대조조)。채용매련면역흡부시험법측정자간전기환자잉만기、임산전급산후혈청VEGF급기sFlt-1수평,병여정상잉부대조비교。결과량조재잉만기급임산전적VEGF、sFlt-1수평비교,차이균유통계학의의(P<O.01)。경도자간전기여중도자간전기환자재잉만기급임산전적VEGF、sFlt-1수평비교,차이야균유통계학의의(P<0.01)。량조재산후적VEGF、sFlt-1수평비교차이균무통계학의의(P>0.05)。결론자간전기환자혈청중sFlt-1수평우잉만기급임산전교정상잉부명현증고,이VEGF수평강저,제시VEGF、sFlt-1가작위진단자간전기적지표지일。
Objective:To investigate the level of serum in VEGF and its receptor SFlt-1 in pregnant women with preeclampsia disease and the significance there of.Method:This study is to focus on 60 high blood pressure pregnant women (i.e.the study group)in the Central Hospital during August 8,2011 through March,2012,wherein the study involves 30 Preeclampsia women in early pregnancy,30 Preeclampsia women in late pregnancy,and 30 regular women in late pregnancy (i.e.the contrast group).The enzyme-linked immunosorbent assay(ELISA)is adopted to detect serum levels in VEGF and its sFlt-1 in women with Preeclampsia disease in every stages of pregnancy:early stage of pregnancy,late stage of pregnancy,pre-natal days,post-natal days.After that,the results of detection are compared to a group of regular women.Results:The results show dif erences in VEGF,SFlt-1 levels in late pregnancy stage and pre-natal stage of the two groups of pregnant women and the dif erences are statistical y significant (P<0.01 >).Conclusions:The conclusion of this study is that the level of sFlt-1 in serum of pre-eclampsia patient in late pregnant stage significant higher than the level of sFlt-1 in a regular pregnant women,whereas the VEGF level goes down.This shows that VEGF,sFlt-1 can be used as indicators for diagnosing a preeclampsia patient.