CAJ | 학술논문

目的探讨同型半胱氨酸（Hcy）水平与多囊卵巢综合症（PCOS）、早期妊娠流产（EPL）的相关性。方法收集PCOS患者123例，其中既往有一次或一次以上12周内流产的患者65例（PCOS流产组），有正常妊娠史的患者58例（PCOS非流产组），另外选取同期既往有一次或一次以上12周内流产并排除PCOS的患者147例（非PCOS流产组）。采用循环酶法检测三组 Hcy 水平并比较。结果 PCOS 流产组 Hcy 水平（14．69±3．91）明显高于PCOS非流产组（11．67±2．93）和非PCOS组流产组（13．14 ± 3．37），且非PCOS流产组显著高于PCOS非流产组，其差异均有统计学意义（ P ＜0．05）。结论高Hcy水平是导致EPL发生的危险因素，可作为预测早期妊娠结局的指标。
목적 탐토동형반광안산（Hcy）수평여다낭란소종합증（PCOS）、조기임신유산（EPL）적상관성。방법 수집PCOS환자123례，기중기왕유일차혹일차이상12주내유산적환자65례（PCOS유산조），유정상임신사적환자58례（PCOS비유산조），령외선취동기기왕유일차혹일차이상12주내유산병배제PCOS적환자147례（비PCOS유산조）。채용순배매법검측삼조 Hcy 수평병비교。결과 PCOS 유산조 Hcy 수평（14．69±3．91）명현고우PCOS비유산조（11．67±2．93）화비PCOS조유산조（13．14 ± 3．37），차비PCOS유산조현저고우PCOS비유산조，기차이균유통계학의의（ P ＜0．05）。결론 고Hcy수평시도치EPL발생적위험인소，가작위예측조기임신결국적지표。
Objective] To explore the correlation of homocysteine(HCY) level with polycystic ovary syn‐drome(PCOS) and early pregnancy abortion(EPL) .[Methods]Totally 123 patients with PCOS including 65 patients with one or more than one abortion within 12 weeks(PCOS abortion group) and 58 patients with nor‐mal pregnant history(PCOS non‐abortion group) were collected .Other 147 patients with one or more than one abortion within 12 weeks but without PCOS (non‐PCOS abortion group) were selected in the same period . HCY level was detected by enzymatic cycling method and compared among 3 groups .[Results] The level of HCY in PCOS abortion group was obviously higher than that in PCOS non‐abortion group and non‐PCOS abor‐tion group ,and that in non‐PCOS abortion group was markedly higher than that in PCOS non‐abortion group , and there was significant difference( P<0 .05) .[Conclusion]High HCY level is a risk factor for EPL and can be used as the indicator of early pregnancy outcome .