CAJ | 학술논문

目的：考察阿霉素壳寡糖-聚乳酸嫁接物胶团的缓释性能。方法以超声分散法制备嫁接物胶团；以阿霉素为模型药物，透析法制备载药胶团。进行载药胶团体外释放实验，考察壳寡糖-聚乳酸共聚物胶团的缓释性能。结果在壳寡糖-聚乳酸嫁接物中，聚乳酸分子量为5000的两种壳寡糖-聚乳酸嫁接物载药胶团体外释放缓释效果明显。结论壳寡糖-聚乳酸聚合物胶团具有显著的缓释特征。其中聚乳酸分子量为5000的壳寡糖-聚乳酸嫁接物，缓释效果更明显。
목적：고찰아매소각과당-취유산가접물효단적완석성능。방법이초성분산법제비가접물효단；이아매소위모형약물，투석법제비재약효단。진행재약효단체외석방실험，고찰각과당-취유산공취물효단적완석성능。결과재각과당-취유산가접물중，취유산분자량위5000적량충각과당-취유산가접물재약효단체외석방완석효과명현。결론각과당-취유산취합물효단구유현저적완석특정。기중취유산분자량위5000적각과당-취유산가접물，완석효과경명현。
Objective Evaluate the ef iciency of delayed release in vitro of adriamycin chitosan-polylactic acid polymeric micel es.Methods Hypersound dispersion method to prepare the polymeric micel es. Adriamycin as a model drug was then incorporated into the micel es by dialysis. Evaluate the ef iciency of delayed release of adriamycin chitosan-polylactic acid polymeric micel es by in vitro investigation. Results The CSO-PLA micel es with 5000 molecule weight of PLA loading Adr displayed more sustained-release characteristic.Conclusion The micel es loading Adr displayed sustained-release characteristic in vitro. The CSO-PLA (PLA with molecule weight 5000) micel es loading Adr displayed significant sustained-release characteristic.