创伤与急诊电子杂志
創傷與急診電子雜誌
창상여급진전자잡지
Journal of Trauma and Emergency (Electronic Version)
2014年
2期
26-29
,共4页
急性心肌梗死%电化学发光%肌钙蛋白T%肌红蛋白%肌酸激酶同工酶%血清标志物
急性心肌梗死%電化學髮光%肌鈣蛋白T%肌紅蛋白%肌痠激酶同工酶%血清標誌物
급성심기경사%전화학발광%기개단백T%기홍단백%기산격매동공매%혈청표지물
Acute myocardial infarction%Electrochemical luminescence%cTnT%Mb%CK-MB%Serum marker
目的：探讨电化学发光法检测血清肌钙蛋白T（cTnT）、肌红蛋白（Mb）、肌酸激酶同工酶（CK-MB）在急性心肌梗死（acute myocardial infarction,AMI）患者中的诊断价值。方法分别对40例健康对照组和48例AMI组患者在胸痛发作后6小时内和6～12小时两个时段的cTnT、Mb、CK-MB进行测定，并统计三项检测指标的敏感性和特异性。结果AMI≤6小时组和6～12小时组cTnT分别为（0.31±0.06）ng/ml和（0.52±0.14）ng/ml，均比对照组（0.01±0.00 ng/ml）显著增高（P＜0.01），并随胸痛后时间增加而增加，二者差别有统计学显著意义（P＜0.01）。AMI≤6小时组和6～12小时组Mb分别为（100.36±31.64 ng/ml）和（161.39±35.51）ng/ml，均比对照组（31.48±8.01）ng/ml显著增高（P＜0.01），并随胸痛后时间增加而增加，二者差别有统计学显著意义（P＜0.01）。AMI≤6小时组和6～12小时组CK-MB分别为（16.82±1.35）ng/ml和（40.14±2.32）ng/ml，均比对照组（2.01±0.51）ng/ml显著增高（P＜0.01），并随着胸痛后时间增加而增加，二者差别有统计学显著意义（P＜0.01）。三项指标中cTnT的敏感性和特异性为95.64%和98.56%，分别高于Mb的92.68%和84.56%以及CK-MB的81.63%和83.69%。结论电化学发光法检测cTnT、Mb、CK-MB可以早期诊断AMI，其中cTnT的敏感性和特异性最高。
目的：探討電化學髮光法檢測血清肌鈣蛋白T（cTnT）、肌紅蛋白（Mb）、肌痠激酶同工酶（CK-MB）在急性心肌梗死（acute myocardial infarction,AMI）患者中的診斷價值。方法分彆對40例健康對照組和48例AMI組患者在胸痛髮作後6小時內和6～12小時兩箇時段的cTnT、Mb、CK-MB進行測定，併統計三項檢測指標的敏感性和特異性。結果AMI≤6小時組和6～12小時組cTnT分彆為（0.31±0.06）ng/ml和（0.52±0.14）ng/ml，均比對照組（0.01±0.00 ng/ml）顯著增高（P＜0.01），併隨胸痛後時間增加而增加，二者差彆有統計學顯著意義（P＜0.01）。AMI≤6小時組和6～12小時組Mb分彆為（100.36±31.64 ng/ml）和（161.39±35.51）ng/ml，均比對照組（31.48±8.01）ng/ml顯著增高（P＜0.01），併隨胸痛後時間增加而增加，二者差彆有統計學顯著意義（P＜0.01）。AMI≤6小時組和6～12小時組CK-MB分彆為（16.82±1.35）ng/ml和（40.14±2.32）ng/ml，均比對照組（2.01±0.51）ng/ml顯著增高（P＜0.01），併隨著胸痛後時間增加而增加，二者差彆有統計學顯著意義（P＜0.01）。三項指標中cTnT的敏感性和特異性為95.64%和98.56%，分彆高于Mb的92.68%和84.56%以及CK-MB的81.63%和83.69%。結論電化學髮光法檢測cTnT、Mb、CK-MB可以早期診斷AMI，其中cTnT的敏感性和特異性最高。
목적：탐토전화학발광법검측혈청기개단백T（cTnT）、기홍단백（Mb）、기산격매동공매（CK-MB）재급성심기경사（acute myocardial infarction,AMI）환자중적진단개치。방법분별대40례건강대조조화48례AMI조환자재흉통발작후6소시내화6～12소시량개시단적cTnT、Mb、CK-MB진행측정，병통계삼항검측지표적민감성화특이성。결과AMI≤6소시조화6～12소시조cTnT분별위（0.31±0.06）ng/ml화（0.52±0.14）ng/ml，균비대조조（0.01±0.00 ng/ml）현저증고（P＜0.01），병수흉통후시간증가이증가，이자차별유통계학현저의의（P＜0.01）。AMI≤6소시조화6～12소시조Mb분별위（100.36±31.64 ng/ml）화（161.39±35.51）ng/ml，균비대조조（31.48±8.01）ng/ml현저증고（P＜0.01），병수흉통후시간증가이증가，이자차별유통계학현저의의（P＜0.01）。AMI≤6소시조화6～12소시조CK-MB분별위（16.82±1.35）ng/ml화（40.14±2.32）ng/ml，균비대조조（2.01±0.51）ng/ml현저증고（P＜0.01），병수착흉통후시간증가이증가，이자차별유통계학현저의의（P＜0.01）。삼항지표중cTnT적민감성화특이성위95.64%화98.56%，분별고우Mb적92.68%화84.56%이급CK-MB적81.63%화83.69%。결론전화학발광법검측cTnT、Mb、CK-MB가이조기진단AMI，기중cTnT적민감성화특이성최고。
Objective To discuss the value of early diagnosis with electrochemical luminescence method to detect the serum troponin T (cTnT), myoglobin (Mb), creatine kinase isoenzyme (CK-MB) in patients with acute myocardial infarction (AMI).Method The value of cTnT, Mb, CK-MB were respectively detected in 40 healthy cases as control group and 48 cases of patients with AMI as experimental group at two time points, within 6 h and 6~12 h after onset of chest pain. The sensitivity and specificity of three indicators were analyzed respectively. Result The value of cTnT are(0.31±0.06)ng/ml and(0.52±0.14) ng/ml in AMI ≤6h group and 6~12 h group respectively, which are significantly higher than that of the control group (0.01±0.00 ng/ml) (P< 0.01). The value of cTnT increases significantly (P< 0.01) as the time after the onset of chest pain goes. The value of Mb are(100.36±31.64)ng/ml and(161.39 ±35.51)ng/ml in AMI≤6h group and 6~12 h group respectively which are significantly higher than that of the control group (31.48±8.01)ng/ml (P< 0.01). The value of Mb increased by statistically significant (P< 0.01) as the time after the onset of chest pain goes. The value of CK-MB are(16.82±1.35)ng/ml and(40.14±2.32)ng/ml in AMI ≤6h group and 6~12 h group respectively which are significantly higher than that of the control group (2.01±0.51)ng/ml (P< 0.01). The value of CK-MB increases significantly (P< 0.01) as the time after the onset of chest pain goes. The sensitivity and specificity of cTnT are 95.64% and 98.56% which are higher than 92.68% and 84.56% of Mb and 81.63% and 83.69% of CK-MB.Conclusion Detection of cTnT, Mb, CK-MB using electrochemical luminescence method could diagnose AMI at early stage. The label of cTnT has the highest sensitivity and specificity in these three labels.
