CAJ | 학술논문

细胞因子是由免疫细胞和某些非免疫细胞经刺激而合成、分泌的一类具有广泛生物学活性的小分子蛋白质，其作为细胞间信号传递分子，主要参与调节免疫应答、免疫细胞分化发育、组织修复、介导炎症反应、刺激造血功能等。microRNA（miRNA）是存在于真核细胞内的一种非编码小RNA，可以调控基因转录后的表达，同时还可作为不同生理和病理状态的分子标记。许多研究表明，细胞因子相关基因的多态性与结核感染、肺结核发病易感性密切相关，而miRNA在肺部疾病的正负调节功能与肺部疾病感染的发生、发展、转化与治疗有关。我们简要叙述了细胞因子、miRNA与结核分枝杆菌感染三者之间的关联，以期有利于及时筛查潜伏结核感染和肺结核患者，降低结核感染率和发病率。
세포인자시유면역세포화모사비면역세포경자격이합성、분비적일류구유엄범생물학활성적소분자단백질，기작위세포간신호전체분자，주요삼여조절면역응답、면역세포분화발육、조직수복、개도염증반응、자격조혈공능등。microRNA（miRNA）시존재우진핵세포내적일충비편마소RNA，가이조공기인전록후적표체，동시환가작위불동생리화병리상태적분자표기。허다연구표명，세포인자상관기인적다태성여결핵감염、폐결핵발병역감성밀절상관，이miRNA재폐부질병적정부조절공능여폐부질병감염적발생、발전、전화여치료유관。아문간요서술료세포인자、miRNA여결핵분지간균감염삼자지간적관련，이기유리우급시사사잠복결핵감염화폐결핵환자，강저결핵감염솔화발병솔。
Cytokine is a kind of small molecule protein with a broad range of biological activies, which can se?creted with stimulation by the immune cells and parts of non-immune cells, and mainly participate in immune re?sponse, differentiation and development immune cells, tissue repair, inflammation-mediated and stimulation of hema?topoietic function as signaling molecules among cells. microRNA(miRNA) is a kind of non-coding small RNA in the eukaryotic cells, which can regulate gene expression after transcription, and miRNA were regarded as molecu?lar markers of different physiological and pathological states. Previous studies have shown that tuberculosis infec?tion and pathogenesis of pulmonary tuberculosis associate with cytokine genes polymorphism closely, and the posi?tive or negative regulatory function of miRNA related the infection, development and transformation of lung dis?ease. In this study, the work focusing on the relationship among cytokine, miRNA and Mycobacterium tuberculosis infection, which will be screening latent tuberculosis infection and pulmonary tuberculosis patients timely and re?ducing tuberculosis infection rate or morbidity.