CAJ | 학술논문

ABC细胞膜转运蛋白是一个能转运多种底物的蛋白质家族，其在宿主对异物的防御机制和肿瘤细胞对抗癌药物的耐药性中发挥重要作用。ABC转运蛋白能将已进人细胞的外源性物质从胞内泵出胞外，是造成肿瘤细胞多药耐药的主要原因，其基因表达水平与细胞内药物浓度和耐药程度密切相关。近年来，肿瘤细胞多药耐药性研究炙手可热。我们简要综述ABC细胞膜转运蛋白的特点、分布、表达及其介导的细胞多药耐药方面的研究进展。
ABC세포막전운단백시일개능전운다충저물적단백질가족，기재숙주대이물적방어궤제화종류세포대항암약물적내약성중발휘중요작용。ABC전운단백능장이진인세포적외원성물질종포내빙출포외，시조성종류세포다약내약적주요원인，기기인표체수평여세포내약물농도화내약정도밀절상관。근년래，종류세포다약내약성연구자수가열。아문간요종술ABC세포막전운단백적특점、분포、표체급기개도적세포다약내약방면적연구진전。
ABC transporters are a class of membrane transport proteins which can transport a variety of sub?strates. ABC transporters play an pivital role in the host defense mechanism and tumor cell resistance to antican?cer drugs. Since ABC transporters can pump intra-cellular exogenous substances to the extracellular enviroment, it is considered the main reason responsible for the multidrug resistance of tumor cells. Which is more, the intracel?lular drug concentration and the drug resistance degree were closely related to the gene expression level of ABC transporters. In recent years, the study of multi-drug resistant tumor cells became a hotspot, a lot of experiments research has been accomplished by domestic and foreign scholars on the multidrug resistance of tumor cells in?duced by ABC transporters. This paper briefly reviewed the characteristics, distribution, expression, and some prog?ress of ABC transporters with regard to tumor multidrug resistance.