世界科技研究与发展
世界科技研究與髮展
세계과기연구여발전
WORLD SCI-TECH R & D
2014年
6期
664-667
,共4页
张正潮%段建敏%卢建中%张效通%范康武
張正潮%段建敏%盧建中%張效通%範康武
장정조%단건민%로건중%장효통%범강무
膀胱癌%成纤维细胞生长因子受体1%成纤维细胞生长因子受体3%Pokemon蛋白%免疫组织化学
膀胱癌%成纖維細胞生長因子受體1%成纖維細胞生長因子受體3%Pokemon蛋白%免疫組織化學
방광암%성섬유세포생장인자수체1%성섬유세포생장인자수체3%Pokemon단백%면역조직화학
bladder cancer%FGFR1%FGFR3%pokemon protein%immunohistochemistry
目的:通过观察FGFR1、FGFR3和Pokemon在膀胱癌组织的表达情况,探讨它们在膀胱癌发生、发展中的作用。方法采用免疫组化检测296例膀胱癌和48例正常膀胱组织中FGFR1、FGFR3和Pokemon蛋白的表达情况。结果1)FGFR1在膀胱癌不同病理分期、分级及初发复发的表达率为:Ta-T1期7.5%,T2-T4期18.1%(p<0.01);低级别2.8%,低-高级别11.9%(p<0.05),高级别14.3%的(p<0.01);初发表达6.8%,复发表达率17.1%(p<0.01)。2)FGFR3在膀胱癌不同病理分期、分级的表达率为:Ta-T1期68.1%,T2-T4期35.0%(p<0.01));低级别75.0%,低-高级别60.3%(p<0.05),高级别44.9%(p<0.01)。3)Pokemon在膀胱癌不同病理分级及初发复发的表达率为:低级别47.2%,低-高级别66.7%(p<0.01),高级别80.6%(p<0.01);初发59.2%,复发80.0%(p<0.01)。结论 FGFR1在膀胱癌中的表达与病理分级、分期成正相关,复发表达明显高于初发;Pokemon在膀胱尿路上皮癌中的表达与病理分级成正相关,复发表达也明显高于初发,表明它们可能主要参与膀胱癌发展及转移等过程。FGFR3在膀胱癌中的表达与病理分级、分期成负相关,表明它可能在膀胱癌发展早期及低级别肿瘤发展中发挥着重要作用。
目的:通過觀察FGFR1、FGFR3和Pokemon在膀胱癌組織的錶達情況,探討它們在膀胱癌髮生、髮展中的作用。方法採用免疫組化檢測296例膀胱癌和48例正常膀胱組織中FGFR1、FGFR3和Pokemon蛋白的錶達情況。結果1)FGFR1在膀胱癌不同病理分期、分級及初髮複髮的錶達率為:Ta-T1期7.5%,T2-T4期18.1%(p<0.01);低級彆2.8%,低-高級彆11.9%(p<0.05),高級彆14.3%的(p<0.01);初髮錶達6.8%,複髮錶達率17.1%(p<0.01)。2)FGFR3在膀胱癌不同病理分期、分級的錶達率為:Ta-T1期68.1%,T2-T4期35.0%(p<0.01));低級彆75.0%,低-高級彆60.3%(p<0.05),高級彆44.9%(p<0.01)。3)Pokemon在膀胱癌不同病理分級及初髮複髮的錶達率為:低級彆47.2%,低-高級彆66.7%(p<0.01),高級彆80.6%(p<0.01);初髮59.2%,複髮80.0%(p<0.01)。結論 FGFR1在膀胱癌中的錶達與病理分級、分期成正相關,複髮錶達明顯高于初髮;Pokemon在膀胱尿路上皮癌中的錶達與病理分級成正相關,複髮錶達也明顯高于初髮,錶明它們可能主要參與膀胱癌髮展及轉移等過程。FGFR3在膀胱癌中的錶達與病理分級、分期成負相關,錶明它可能在膀胱癌髮展早期及低級彆腫瘤髮展中髮揮著重要作用。
목적:통과관찰FGFR1、FGFR3화Pokemon재방광암조직적표체정황,탐토타문재방광암발생、발전중적작용。방법채용면역조화검측296례방광암화48례정상방광조직중FGFR1、FGFR3화Pokemon단백적표체정황。결과1)FGFR1재방광암불동병리분기、분급급초발복발적표체솔위:Ta-T1기7.5%,T2-T4기18.1%(p<0.01);저급별2.8%,저-고급별11.9%(p<0.05),고급별14.3%적(p<0.01);초발표체6.8%,복발표체솔17.1%(p<0.01)。2)FGFR3재방광암불동병리분기、분급적표체솔위:Ta-T1기68.1%,T2-T4기35.0%(p<0.01));저급별75.0%,저-고급별60.3%(p<0.05),고급별44.9%(p<0.01)。3)Pokemon재방광암불동병리분급급초발복발적표체솔위:저급별47.2%,저-고급별66.7%(p<0.01),고급별80.6%(p<0.01);초발59.2%,복발80.0%(p<0.01)。결론 FGFR1재방광암중적표체여병리분급、분기성정상관,복발표체명현고우초발;Pokemon재방광뇨로상피암중적표체여병리분급성정상관,복발표체야명현고우초발,표명타문가능주요삼여방광암발전급전이등과정。FGFR3재방광암중적표체여병리분급、분기성부상관,표명타가능재방광암발전조기급저급별종류발전중발휘착중요작용。
Objective By the study on protein expression of FGFR1 ,FGFR3 and Pokemon in bladder cancer,to identify their function in the development role of bladder cancer.Methods Immunohistochemistry was used to detect FGFR1 ,FGFR3 and Pokemon protein in 296 cases of bladder cancer and 48 cases of normal bladder tissue.Results 1 )FGFR1 bladder cancer in different pathological stage,grade and onset recurrent expression was:Ta-T1 7. 5%,T2-T4 1 8. 1% (p<0. 01 );low level 2. 8%,low-high level 1 1 . 9% (p<0. 05),high-level 1 4.3% (p<0. 01 );early publication 6.8%,the recurrence expres-sion 1 7. 1% (p<0. 01 ).2 )FGFR3 in various pathological staging of bladder cancer,grading expression was:Ta-T1 68. 1%,T2-T4 35. 0% (p<0. 01 );low-level 75. 0% ,low-High level 60. 3% (p<0. 05 ),high level 44. 9% (p<0. 01 ).3.Pokemon in different pathological grading of bladder cancer recurrence and the onset of expression was:47. 2%low-level,low-High level 66. 7%(p<0. 01 ),high-level 80. 6%(p<0. 01 );initial issuance 59. 2%,relapse 80.0%(p<0. 01 ).Conclusion FGFR1 expression and tumor grade in bladder cancer,staging a positive correlation,relapse was signifi-cantly higher than the initial issuance;Pokemon expression was positively correlated with tumor grade,recurrence expression was also significantly higher than the onset of bladder urothelial carcinoma,suggesting that they may be mainly involved in the process of developing bladder cancer and metastasis.FGFR3 expression and tumor grade,stage a negative correlation in bladder cancer,suggesting that it may develop in the early stage of bladder cancer and low-grade tumor development plays an important role.