CAJ | 학술논문

目的：分析粤西地区汉族人群 NINJ2基因功能单核苷酸多态性（Functional SNP，F-SNP）与脑梗死的关联性。方法采用FASTSNP软件筛选神经损伤诱导蛋白基因2（NINJ2）的F-SNPs（rs34578646 A／G和rs3809263 A／G）。联合聚合酶链反应-限制性片段长度多态性（PCR-RFLP）和等位基因特异性 PCR（AS-PCR）方法，对278例脑梗死患者（病例组）和120例正常对照者（对照组）进行 F-SNPs 基因型检测。结果病例组 rs34578646 A／G 和rs3809263 A／G 的基因型频率和等位基因频率与对照组相比较差异无统计学意义（P＞0．05）。结论粤西地区汉族人群 NINJ2基因功能单核苷酸多态性 rs34578646 A／G以及 rs3809263 A／G与脑梗死无关。
목적：분석월서지구한족인군 NINJ2기인공능단핵감산다태성（Functional SNP，F-SNP）여뇌경사적관련성。방법채용FASTSNP연건사선신경손상유도단백기인2（NINJ2）적F-SNPs（rs34578646 A／G화rs3809263 A／G）。연합취합매련반응-한제성편단장도다태성（PCR-RFLP）화등위기인특이성 PCR（AS-PCR）방법，대278례뇌경사환자（병례조）화120례정상대조자（대조조）진행 F-SNPs 기인형검측。결과병례조 rs34578646 A／G 화rs3809263 A／G 적기인형빈솔화등위기인빈솔여대조조상비교차이무통계학의의（P＞0．05）。결론월서지구한족인군 NINJ2기인공능단핵감산다태성 rs34578646 A／G이급 rs3809263 A／G여뇌경사무관。
Objective To investigate the relationship between cerebral infarction (CI)and the functional single nu-cleotide polymorphisms(F-SNPs )of NINJ2 gene in Han population of the Western Guangdong province in China. Methods The F-SNPs of NINJ2 gene (rs34578646 A/G and rs3809263 A/G)was screened by FASTSNP software. Genotype and allele frequency was analysis in 278 cerebral infarction cases and 120 healthy controls.Results The fre-quencies of genotypes and allele in two polymorphisms (rs34578646 A/G and rs3809263 A/G)showed an insignificant difference between case and control groups(P>0.05).Conclusion Two F-SNPs of NINJ2 gene (rs34578646 A/G and rs3809263 A/G)were not associated with the risk of ischemic stroke.