CAJ | 학술논문

目的：探讨麻芍平喘汤对支气管哮喘大鼠气道重塑及血清IL-5、IL-13的影响。方法：雄性SD大鼠70只随机分为正常组、模型组、地塞米松组、阳和平喘组和麻芍平喘高、中、低剂量组，每组10只，造模28天后，正常组、模型组每天给予生理盐水灌胃，其他各组给予相应药物灌胃，2周后解剖大鼠并取出肺组织。结果：模型组肺组织病理学改变明显，对大鼠血清中IL-5和IL-13的影响麻芍平喘汤各剂量组与模型组比较差异有统计学意义（P＜0.05），中药组与地塞米松组比较差异有统计学意义（P＜0.05），麻芍平喘高剂量组与阳和平喘组比较差异无统计学意义（P＞0.05）。结论：麻芍平喘汤具有减轻哮喘气道炎症，干预气道重塑的作用。
목적：탐토마작평천탕대지기관효천대서기도중소급혈청IL-5、IL-13적영향。방법：웅성SD대서70지수궤분위정상조、모형조、지새미송조、양화평천조화마작평천고、중、저제량조，매조10지，조모28천후，정상조、모형조매천급여생리염수관위，기타각조급여상응약물관위，2주후해부대서병취출폐조직。결과：모형조폐조직병이학개변명현，대대서혈청중IL-5화IL-13적영향마작평천탕각제량조여모형조비교차이유통계학의의（P＜0.05），중약조여지새미송조비교차이유통계학의의（P＜0.05），마작평천고제량조여양화평천조비교차이무통계학의의（P＞0.05）。결론：마작평천탕구유감경효천기도염증，간예기도중소적작용。
[Abstrac] Objective:Research on Mashaopingchuan decoction to airway remodelling and IL-5、IL-13 in asthmatic rats. Methods:70 male SD rats were randomLy divided into 7 groups:normal group,model group,hexadecadrol group;Yang HE learns group;Mashaopingchuan decoction high dose group,Mashaopingchuan decoction middle dose group;Mashaopingchuan decoction low dose group.After make model 28 days,normal group and model group were gived normal saline every day;others were gived relevant medicine.2 weeks anatomy rats and bring out lung tissue.Results:The model group of lung tissue pathology changed obviously;The influence of IL-5 and IL-13 in rats serum;Mashaopingchuan decoction groups compared with model group had significant difference(P<0.05),Chinese medicine groups compared with model group had obviously difference (P<0.05),Mashaopingchuan decoction high dose group compared with Yang HE learns group no difference(P>0.05). Conclusion:Mashaopingchuan Decoction could relieve asthma airway inflammation,intervention airway remodelling.