CAJ | 학술논문

目的：探讨右美托咪定用于防治剖宫产术中寒战反应的适宜剂量。方法选择单胎足月妊娠，拟在连续硬膜外麻醉下行择期剖宫产术的孕妇120例，随机分为四组，每组30例。胎儿娩出后，D1、D2、D3组分别输注负荷量右美托咪定0.2、0.5、0.8μg／kg，输注时间10 min，继以0.4μg·kg－1·h－1持续输注，关腹完毕后停药。N 组则以0.1 ml·kg－1·h－1的速率输注生理盐水。记录输注右美托咪定15 min 时产妇的寒战分级。结果D2组和 D3组寒战的发生率和程度分别低于 D1组和 N 组（P＜0.05），而 D2组和 D3组差异无统计学意义。结论右美托咪定可有效防治剖宫术中寒战的发生，负荷量0.5μg／kg 是一适宜剂量。
목적：탐토우미탁미정용우방치부궁산술중한전반응적괄의제량。방법선택단태족월임신，의재련속경막외마취하행택기부궁산술적잉부120례，수궤분위사조，매조30례。태인면출후，D1、D2、D3조분별수주부하량우미탁미정0.2、0.5、0.8μg／kg，수주시간10 min，계이0.4μg·kg－1·h－1지속수주，관복완필후정약。N 조칙이0.1 ml·kg－1·h－1적속솔수주생리염수。기록수주우미탁미정15 min 시산부적한전분급。결과D2조화 D3조한전적발생솔화정도분별저우 D1조화 N 조（P＜0.05），이 D2조화 D3조차이무통계학의의。결론우미탁미정가유효방치부궁술중한전적발생，부하량0.5μg／kg 시일괄의제량。
Objective To study the optimal dose of dexmedetomidine for preventing of shive-ring during caesarean section under epidural anesthesia.Methods One hundred and twenty ASA Ⅰ orⅡ parturients with a single baby at full term in vertex presentation,scheduled for caesarean section under continuous epidural anesthesia,were randomly divided into 4 groups (n=30 each):group D1, group D2,group D3 and group N (control group).After delivery of the baby,The group D1,group D2 and group D3 were received an intravenous infusion loading dose of 0.2μg/kg,0.5μg/kg and 0.8μg/kg of dexmedetomidine within 10 minutes respectively,and following with an intravenous infusion 0.4 μg·kg-1·h-1 of dexmedetomidine until peritoneal closure.The group N received an intravenous infusion 0.1 ml·kg-1·h-1 of normal saline.Results The incidence and degree of shivering in group D2 and group D3 were lower than those in group D1 and group N(P<0.05),but there were no statistics differences between group D2 and group D3.Conclusion Administration of dexmedetomidine can re-duce the occurrence of shivering during caesarean section under epidural anesthesia,and a loading dose of 0.5 μg/kg of dexmedetomidine is the optimal dose.