CAJ | 학술논문

目的：研究性别对癫痫手术患者顺式阿曲库铵剂量-反应曲线的影响。方法选取择期癫痫手术患者80例，年龄17～42岁，病史3～26年，分为男性组（M 组）和女性组（F 组），每组按20、30、40、50μg／kg 再分为四个亚组（M1～M4组和 F1～F4组），每组10例。记录拇内收肌四个成串刺激（TOF）第一次反应最大抑制的百分率，并进行概率单位转换，将顺式阿曲库铵的首次剂量进行对数转换，用直线回归方法分别建立男、女患者顺式阿曲库铵剂量-反应曲线，并记录起效时间。结果M组顺式阿曲库铵单次剂量静注 ED50、ED75、ED90、ED95值分别为（37.2±9.7）、（48.1±11.3）、（60.4±12.8）、（69.3±14.0）μg／kg，F 组分别为（36.6±4.3）、（47.5±7.7）、（60.5±14.0）、（70.1±19.4）μg／kg，两组差异无统计学意义。两组患者肌松起效时间差异无统计学意义。结论性别不影响癫痫患者顺式阿曲库铵的剂量-反应曲线。
목적：연구성별대전간수술환자순식아곡고안제량-반응곡선적영향。방법선취택기전간수술환자80례，년령17～42세，병사3～26년，분위남성조（M 조）화녀성조（F 조），매조안20、30、40、50μg／kg 재분위사개아조（M1～M4조화 F1～F4조），매조10례。기록무내수기사개성천자격（TOF）제일차반응최대억제적백분솔，병진행개솔단위전환，장순식아곡고안적수차제량진행대수전환，용직선회귀방법분별건립남、녀환자순식아곡고안제량-반응곡선，병기록기효시간。결과M조순식아곡고안단차제량정주 ED50、ED75、ED90、ED95치분별위（37.2±9.7）、（48.1±11.3）、（60.4±12.8）、（69.3±14.0）μg／kg，F 조분별위（36.6±4.3）、（47.5±7.7）、（60.5±14.0）、（70.1±19.4）μg／kg，량조차이무통계학의의。량조환자기송기효시간차이무통계학의의。결론성별불영향전간환자순식아곡고안적제량-반응곡선。
Objective To evaluate the gender differences in dose-response curve with cisatra-curium in epileptics.Methods Eighty ASA grade Ⅰ or Ⅱ epileptics were enrolled in this study.All patients were divided into male and the female groups and received the method of single dose injection under midazolam-fentanyl intravenous anesthesia.Each patient received intravenous bolus of 20,30, 40,50μg/kg of cisatracurium respectively.The neuromuscular block was measured by Neuromuscular Transmission Monitor and the responses were defined in terms of the percentages of maximum sup-pression in T1 of TOF of the adductor pollicis muscle.According to log-probit transformation of the data of dose and response,the dose-response curve of cisatracurium was established through linear re-gression.The onset time of cisatracurium was also observed.Results The ED50 ,ED75 ,ED90 ,ED95 values of cisatracurium in male epilepsy patients were 37.2±9.7,48.1±11.3,60.4±12.8,69.3± 14.0 μg/kg and that of female epilepsy patients were 36.6±4.3,47.5±7.7,60.5±14.0,70.1± 19.4 μg/kg.There was no significant difference between the two gender groups.No significant change in onset time was observed among 4 dose groups.Conclusion No gender differences are ob-served in dose-response curve of cisatracurium in epileptics.