CAJ | 학술논문

目的：观察快速序贯诱导（RSI）前预注右美托咪定对插管条件及血流动力学的影响。方法选择40例择期全麻妇科手术患者，年龄25～50岁，随机分为两组，每组20例。D 组诱导前泵注右美托咪定0.6μg／kg（10 min 泵完），C 组泵注等量生理盐水10 ml，泵注期间给予面罩高流量吸氧5 L／min；泵注完毕后实施 RSI。记录插管时间和喉镜暴露分级，以及泵注前及泵注后15 min 内每分钟的 MAP、HR、BIS、SpO2；检测 PaO2和 PaCO2。结果两组插管时间和喉镜暴露分级差异无统计学意义。插管后14、15 min，C 组 MAP 较 D 组明显下降，HR 明显增快（P＜0.05）。插管期间两组SpO2和 PaO2差异无统计学意义。D 组呛咳发生率明显低于 C 组（P＜0.05）。结论RSI 前预注右美托咪定0.6μg／kg 可以在不影响机体氧储备的前提下，减少插管时的血流动力学波动和插管时间。
목적：관찰쾌속서관유도（RSI）전예주우미탁미정대삽관조건급혈류동역학적영향。방법선택40례택기전마부과수술환자，년령25～50세，수궤분위량조，매조20례。D 조유도전빙주우미탁미정0.6μg／kg（10 min 빙완），C 조빙주등량생리염수10 ml，빙주기간급여면조고류량흡양5 L／min；빙주완필후실시 RSI。기록삽관시간화후경폭로분급，이급빙주전급빙주후15 min 내매분종적 MAP、HR、BIS、SpO2；검측 PaO2화 PaCO2。결과량조삽관시간화후경폭로분급차이무통계학의의。삽관후14、15 min，C 조 MAP 교 D 조명현하강，HR 명현증쾌（P＜0.05）。삽관기간량조SpO2화 PaO2차이무통계학의의。D 조창해발생솔명현저우 C 조（P＜0.05）。결론RSI 전예주우미탁미정0.6μg／kg 가이재불영향궤체양저비적전제하，감소삽관시적혈류동역학파동화삽관시간。
Objective To investigate the effects of dexmedetomidine on hemodynamics and tra-cheal intubation facility in general anesthetized patients.Methods Forty gynecological patients of se-lective operation under general anesthesia were randomly arranged into 2 groups:group D and group C.With high flow mask oxygen inhalation(5 L/min),dexmedetomidine was intravenously pumped in-to the patients in group D at 0.6μg/kg in 10 minutes while in group C saline were given instead.Both groups were then proceeded with rapid sequence induction (RSI)immediately.The values of MAP, HR,PaO2 and PaCO2 were recorded every minute from pumping start till 15 minutes,the bucking, intubation time and glottis exposure were evaluated as well.Results No significant differences were found in intubation time or glottis exposure between these two groups.After tracheal intubation group D showed higher MAP value than group C at 14,15 minutes,and a lower HR value (P <0.05).Even no significant differences were found in values of SpO2 and PaO2 ,the group D showed less bucking than the group C (P<0.05).Conclusion Dexmedetomidine administration at 0.6μg/kg in RSI can diminish the variation in hemodynamics and facilitate the tracheal intubation by less buc-king,but no affect the oxygen reserve.