CAJ | 학술논문

目的：观察调强放疗联合周剂量顺铂治疗老年人食管癌的近期疗效和毒副反应。方法将60例局部晚期老年食管癌患者采用数字表法随机分为同步放化疗组（ CRT组）30例和单纯放疗组（ RT组）30例，两组均采用6MV－X射线调强放疗，放疗剂量：DT 60 Gy／30次／6周。 CRT组在放疗第2天开始给予顺铂20～25 mg／m2，1次／周，共6次。结果 CRT组、RT组近期有效率分别为80．0％、63．3％，差异有统计学意义（χ2＝5．934，P＜0．05）。不良反应主要为骨髓抑制、放射性食管炎，基本为Ⅰ～Ⅱ级，两组不良反应差异无统计学意义（P＞0．05）。结论调强放疗联合周剂量顺铂治疗老年人食管癌近期疗效显著，不良反应轻，患者耐受性好，值得临床推广。
목적：관찰조강방료연합주제량순박치료노년인식관암적근기료효화독부반응。방법장60례국부만기노년식관암환자채용수자표법수궤분위동보방화료조（ CRT조）30례화단순방료조（ RT조）30례，량조균채용6MV－X사선조강방료，방료제량：DT 60 Gy／30차／6주。 CRT조재방료제2천개시급여순박20～25 mg／m2，1차／주，공6차。결과 CRT조、RT조근기유효솔분별위80．0％、63．3％，차이유통계학의의（χ2＝5．934，P＜0．05）。불량반응주요위골수억제、방사성식관염，기본위Ⅰ～Ⅱ급，량조불량반응차이무통계학의의（P＞0．05）。결론조강방료연합주제량순박치료노년인식관암근기료효현저，불량반응경，환자내수성호，치득림상추엄。
Objective To observe the near future curative effect and toxicity of the combination of weekly dose of cisplatin in the treatment of elderly patients with esophageal cancer intensity-modulated radiotherapy observa-tion.Methods 60 patients with locally advanced esophageal cancer patients aged by method randomly were divided into synchronous chemotherapy group( CRT group) and 30 cases of radiotherapy alone group( RT group) 30 cases,the two groups using 6MV-X ray intensity modulated radiotherapy,radiotherapy dose:DT 60 Gy/30/6 week.The CRT treated group was given cisplatin 20-25mg/m2 in the radiotherapy of second day,1 times per week,a total of 6 times. Results Radiotherapy and chemotherapy, radiotherapy group recent effective rate were 80.0% and 63.3%, the difference was statistically significant(χ2 =5.934,P<0.05),P&lt 0.05).The main toxicity was myelosuppres-sion,radiation esophagitis,basically I and II,no statistically significant difference between the two groups(P>0.05). Conclusion Intensity modulated radiotherapy combined with weekly dose of cisplatin in the treatment of elderly patients with esophageal cancer significant short-term effect,less adverse reactions,patient tolerance is good,which is worth the clinical promotion.