CAJ | 학술논문

目的：研究5种血清肿瘤标志物在肺癌辅助诊断中的应用价值。方法选取我院在2010年11月~2013年11月收治的62例肺癌患者为研究对象，选取同期收治的肺良性疾病患者62例作为对照，对所有患者的5种血清肿瘤标志物进行检测，检测项目包括NSE(血清神经元特异性烯醇化酶)、CEA(癌胚抗原)、CA125(糖类抗原125)、CA199(糖类癌抗原199)、Cy-fra21-1(细胞角蛋白19片段)。结果肺癌患者在NSE、CEA、CA125、CA199、Cy-fra21-15项指标上均低于肺部良性疾病患者，对比具有统计学意义(<0.05)。5种血清肿瘤标志物联合检测的灵敏度为95.2%，特异度为82.3%，准确度为87.6%。结论经研究得知，通过对患者5种血清肿瘤标志物进行检测，有利于提高肺癌疾病的诊断正确率，值得临床推广应用。
목적：연구5충혈청종류표지물재폐암보조진단중적응용개치。방법선취아원재2010년11월~2013년11월수치적62례폐암환자위연구대상，선취동기수치적폐량성질병환자62례작위대조，대소유환자적5충혈청종류표지물진행검측，검측항목포괄NSE(혈청신경원특이성희순화매)、CEA(암배항원)、CA125(당류항원125)、CA199(당유암항원199)、Cy-fra21-1(세포각단백19편단)。결과폐암환자재NSE、CEA、CA125、CA199、Cy-fra21-15항지표상균저우폐부량성질병환자，대비구유통계학의의(<0.05)。5충혈청종류표지물연합검측적령민도위95.2%，특이도위82.3%，준학도위87.6%。결론경연구득지，통과대환자5충혈청종류표지물진행검측，유리우제고폐암질병적진단정학솔，치득림상추엄응용。
Objective To study the 5 kinds of serum tumor markers in the diagnosis of lung cancer auxiliary application value. Methods Select our hospital in November 2010 to November 2013, 62 cases of patients with lung cancer as the research object, during the same period of 62 patients with lung benign disease were selected as control, for al 5 kinds of serum tumor markers in patients with testing, test items include NSE serum neuron specificity enolization (enzyme) and CEA (carcinoembryonic antigen), CA125 (carbohydrate antigen 125), CA199 cancer antigen 199 (sugar), Cy-fra21-1 (cytokeratin 19 fragment). Results NSE in patients with lung cancer, CEA, CA125, CA199 and Cy- fra21-15 indicators are lower than in patients with lung benign disease, compared with statistical significance ( < 0.05). Five kinds of serum tumor markers combined detection sensitivity of 95.2%, 82.3%, the accuracy is 87.6%. Conclusion The study, based on the five kinds of serum tumor markers in patients with testing, to improve the diagnostic accuracy of lung disease, worthy of clinical popularization and application.