CAJ | 학술논문

目的：：观察卡维地洛对慢性心力衰竭患者血浆和肽素及内皮素( ET)的影响。方法：CHF患者190例,随机分为常规治疗组(94例)及卡维地洛组(96例,在常规治疗的基础上加用卡维地洛)。治疗6个月,比较治疗前后患者心功能变化及血浆和肽素和ET水平的差异。结果：卡维地洛组患者的总有效率明显高于常规治疗组(P<0.05),LVEDd及LVEF均较常规治疗组显著改善(P<0.05)；血浆和肽素及ET水平与常规治疗组比较有显著下降(P<0.05)。结论：卡维地洛可以明显改善CHF患者的心功能,降低血浆和肽素及ET水平。
목적：：관찰잡유지락대만성심력쇠갈환자혈장화태소급내피소( ET)적영향。방법：CHF환자190례,수궤분위상규치료조(94례)급잡유지락조(96례,재상규치료적기출상가용잡유지락)。치료6개월,비교치료전후환자심공능변화급혈장화태소화ET수평적차이。결과：잡유지락조환자적총유효솔명현고우상규치료조(P<0.05),LVEDd급LVEF균교상규치료조현저개선(P<0.05)；혈장화태소급ET수평여상규치료조비교유현저하강(P<0.05)。결론：잡유지락가이명현개선CHF환자적심공능,강저혈장화태소급ET수평。
Objective:To investigate effects of carvedilol on plasma copeptin and endothelin ( ET) in the patients with chronic heart failure ( CHF) . Methods:190 patients with CHF were randomly divided into routine treatment group ( n=94 ) and carvedilol group (n=96, received carvedilol based on the routine treatment). 6 months was regard as a course treatment. The cardiac function and the plasma copeptin and ET were observed and compared in all groups before and after treatment. Results:The total effective rate in carvedilol group was higher than that in routine treatment group (P<0. 05), and the LVEDd and LVEF were more significantly im-proved than routine treatment group (P<0. 05). There were more significant decreases in the plasma copeptin and ET levels in carve-dilol group than in routine treatment group (P<0. 05). Conclusions:Carvedilol can improve cardiac function of the CHF patients, and reduce the levels of plasma copeptin and ET.