CAJ | 학술논문

目的：：探究帕罗西汀联合小剂量奥氮平治疗抑郁症伴失眠患者的临床效果。方法：选取抑郁症伴失眠患者80例为研究对象,按照治疗方式不同分为对照组与观察组,对照组患者给予帕罗西汀治疗,观察组患者在对照组的基础上给予小剂量奥氮平治疗,观察两组患者的治疗效果。结果：两组患者治疗第1、3、6个月后的HAMD评分与PSQI评分比较,P<0.05,治疗后总有效率比较,P<0.05。结论：帕罗西汀联合小剂量奥氮平治疗抑郁症伴失眠临床效果优于单纯帕罗西汀治疗,值得临床推广使用。
목적：：탐구파라서정연합소제량오담평치료억욱증반실면환자적림상효과。방법：선취억욱증반실면환자80례위연구대상,안조치료방식불동분위대조조여관찰조,대조조환자급여파라서정치료,관찰조환자재대조조적기출상급여소제량오담평치료,관찰량조환자적치료효과。결과：량조환자치료제1、3、6개월후적HAMD평분여PSQI평분비교,P<0.05,치료후총유효솔비교,P<0.05。결론：파라서정연합소제량오담평치료억욱증반실면림상효과우우단순파라서정치료,치득림상추엄사용。
Objective:To explore clinical effects of Paroxetine combined with small dose Olanzapine in treatment of depression associated with insomnia. Methods:80 cases with depression associated with insomnia were selected as the research subject and divid-ed into control group and observation group according to different methods of treatment. Control group was given Paroxetine treatment, while observation group was given Paroxetine combined with small dose Olanzapine treatment. The therapeutic effects of the two groups were compared. Results:1, 3 and 6 months after the treatment, the differences of HAMD and PSQI scores of the two groups were sig-nificant (P<0. 05);and the difference of total effective rate of the two groups was significant (P<0. 05). Conclusions: Paroxetine combined with small dose Olanzapine in the treatment of depression associated with insomnia is more effective than single Paroxetine, and is worthy of clinical promotion.