CAJ | 학술논문

目的：应用1 H－MRS技术，研究正常脑老化过程中双侧海马不同部位物质代谢的变化规律。方法对121名健康右利手志愿者，根据年龄分为青年组（20～44岁，47例）、中年组（45～59岁，40例）和老年组（60～79岁，40例）行颅脑MRI、MRS检查，自动测量并计算出海马区不同部位代谢物浓度比值NAA／Cr、Cho／Cr。分析不同性别、不同侧别、年龄组间各统计指标间的差异。结果双侧海马头部NAA／Cr比值在老年组与青年组、老年组与中年组间比较差异有统计学意义（ P ＜0 U．05）；双侧海马体1区、左侧海马体2区、左侧海马尾部NAA／Cr比值仅在青年组与老年组间差异有统计学意义（ P ＜0．05）；海马头、体（体1区、体2区）、尾部年龄组间Cho／Cr比值差异无统计学意义（ P ＞0．05）。双侧海马各部位NAA／Cr、Cho／Cr比值差异无统计学意义（ P ＞0．05）。海马头、体（体1区、体2区）、尾部NAA／Cr、Cho／Cr比值差异无统计学意义（ P ＞0．05）。结论双侧海马不同部位NAA／Cr比值存在年龄组间差异，Cho／Cr比值未见差异；双侧海马各部位NAA／Cr、Cho／Cr比值均不存在性别及侧别差异。
목적：응용1 H－MRS기술，연구정상뇌노화과정중쌍측해마불동부위물질대사적변화규률。방법대121명건강우리수지원자，근거년령분위청년조（20～44세，47례）、중년조（45～59세，40례）화노년조（60～79세，40례）행로뇌MRI、MRS검사，자동측량병계산출해마구불동부위대사물농도비치NAA／Cr、Cho／Cr。분석불동성별、불동측별、년령조간각통계지표간적차이。결과쌍측해마두부NAA／Cr비치재노년조여청년조、노년조여중년조간비교차이유통계학의의（ P ＜0 U．05）；쌍측해마체1구、좌측해마체2구、좌측해마미부NAA／Cr비치부재청년조여노년조간차이유통계학의의（ P ＜0．05）；해마두、체（체1구、체2구）、미부년령조간Cho／Cr비치차이무통계학의의（ P ＞0．05）。쌍측해마각부위NAA／Cr、Cho／Cr비치차이무통계학의의（ P ＞0．05）。해마두、체（체1구、체2구）、미부NAA／Cr、Cho／Cr비치차이무통계학의의（ P ＞0．05）。결론쌍측해마불동부위NAA／Cr비치존재년령조간차이，Cho／Cr비치미견차이；쌍측해마각부위NAA／Cr、Cho／Cr비치균불존재성별급측별차이。
Objective To investigate the regulation of material metabolism changes in different regions of bilateral hippocampus during normal brain aging through proton magnetic resonance spectroscopy (1H-MRS) technique.Methods One hundred and twenty-one right handedness healthy volunteers were enrolled in the study ,according to their age who were divided into youth group (age range:20~44yr, n =47),middle-aged group (age range:45~59yr, n =40),older age group (age range:60~79yr, n =40),all the volunteers were examined by MRI and MRS ,the concentration ratio of metabolite in different regions of bilateral hippocampus ( NAA/Cr and Cho/Cr ) was automatically measured .The differences of the parameters in different sex ,different side and different age groups were statistically analyzed .Results There was a significant difference in the concentration ratio of NAA/Cr in bilateral hippocampal head between older age group and youth group and between older age group and middle age group ( P <0.05).There was a significant difference in the concentration ratio of NAA/Cr in bilateral hippocampal body-region 1,left hippocampal body-region 2 and left hippocampal body tail between older age group and youth group ( P <0.05),however,there was no significant difference in the ratio of Cho /Cr in hippocampal head,body (region 1 and region 2) and tail among the three groups ( P >0.05).There was no significant difference in the ratio of NAA/Cr,Cho/Cr in different regions of bilateral hippocampus ( P >0.05).There was no significant difference in the ratio of NAA/Cr,Cho/Cr in hippocampal head ,body (region 1 and region 2) and tail among the three groups ( P >0.05). Conclusion There is significant difference in the ratio of NAA/Cr in different regions of bilateral hippocampus among different age groups,howevere,there is no significant difference in the ratio of NAA/Cr.Moreover there is no significant difference in ratio of NAA/Cr,Cho/Cr in different regions of bilateral hippocampus between males and females and between left side and right side .