河北医学
河北醫學
하북의학
HEBEI MEDICINE
2015年
3期
369-372
,共4页
轻型地中海贫血%孕%妇%血红蛋白( HGB)%血清铁蛋白( SF)
輕型地中海貧血%孕%婦%血紅蛋白( HGB)%血清鐵蛋白( SF)
경형지중해빈혈%잉%부%혈홍단백( HGB)%혈청철단백( SF)
Light mediterranean anemia%Pregnancy%Hemoglobin ( HGB)%Serum ferritin
目的：探讨轻型地中海贫血孕妇妊娠期血红蛋白（HGB）和血清铁蛋白（SF）变化及临床意义，并分析其对妊娠结局的影响，为轻型地中海贫血孕妇孕期保健提供依据。方法：选择本院2013年1月至2013年10月收治的轻型地中海贫血孕前或孕早期妇女95例（观察组），选择同期在本院住院分娩的430例妊娠合并缺铁性贫血（对照组）和420例孕期血红蛋白正常孕妇（正常组）。分别在孕妇11～13周（孕早期）、24～28周（孕中期）和36～40周（孕晚期）检测各组HGB和血清SF含量，并比较各组妊娠结局。结果：观察组孕早期、孕中期和孕晚期HGB和SF分别为91．94±7．61g／L、86．39±6．84g／L、85．62±7．04g／L和76．47±5．62μg／L、52．18±5．14μg／L和40．82±5．10μg／L，均低于对照组和正常组，对照组低于正常组，差异具有统计学意义（P＜0．05）。观察组HGB和SF下降幅度分别为6．24±1．03g／L和29．40±3．22μg／L，均高于对照组和正常组，差异具有统计学意义（ P＜0．05）。观察组剖宫产、羊水过多／过少、早产儿、足月低体重儿和产后出血分别为50．53％（48／95）、17．89％（17／95）、14．74％（14／95）、12．63％（12／95）和190．81±11．64mL，均高于对照组和正常组，差异具有统计学意义（P＜0．05）。观察组新生儿平均体重为190．81±11．64kg，均低于对照组和正常组，对照组低于正常组，差异具有统计学意义（ P＜0．05）。结论：轻型地中海贫血孕妇妊娠期HGB、SF含量明显减少，且降低幅度显著增高，剖宫产、早产儿明显增加，新生儿平均体重降低，对母婴结局有一定的影响，应加强孕妇的围产期保健。
目的：探討輕型地中海貧血孕婦妊娠期血紅蛋白（HGB）和血清鐵蛋白（SF）變化及臨床意義，併分析其對妊娠結跼的影響，為輕型地中海貧血孕婦孕期保健提供依據。方法：選擇本院2013年1月至2013年10月收治的輕型地中海貧血孕前或孕早期婦女95例（觀察組），選擇同期在本院住院分娩的430例妊娠閤併缺鐵性貧血（對照組）和420例孕期血紅蛋白正常孕婦（正常組）。分彆在孕婦11～13週（孕早期）、24～28週（孕中期）和36～40週（孕晚期）檢測各組HGB和血清SF含量，併比較各組妊娠結跼。結果：觀察組孕早期、孕中期和孕晚期HGB和SF分彆為91．94±7．61g／L、86．39±6．84g／L、85．62±7．04g／L和76．47±5．62μg／L、52．18±5．14μg／L和40．82±5．10μg／L，均低于對照組和正常組，對照組低于正常組，差異具有統計學意義（P＜0．05）。觀察組HGB和SF下降幅度分彆為6．24±1．03g／L和29．40±3．22μg／L，均高于對照組和正常組，差異具有統計學意義（ P＜0．05）。觀察組剖宮產、羊水過多／過少、早產兒、足月低體重兒和產後齣血分彆為50．53％（48／95）、17．89％（17／95）、14．74％（14／95）、12．63％（12／95）和190．81±11．64mL，均高于對照組和正常組，差異具有統計學意義（P＜0．05）。觀察組新生兒平均體重為190．81±11．64kg，均低于對照組和正常組，對照組低于正常組，差異具有統計學意義（ P＜0．05）。結論：輕型地中海貧血孕婦妊娠期HGB、SF含量明顯減少，且降低幅度顯著增高，剖宮產、早產兒明顯增加，新生兒平均體重降低，對母嬰結跼有一定的影響，應加彊孕婦的圍產期保健。
목적：탐토경형지중해빈혈잉부임신기혈홍단백（HGB）화혈청철단백（SF）변화급림상의의，병분석기대임신결국적영향，위경형지중해빈혈잉부잉기보건제공의거。방법：선택본원2013년1월지2013년10월수치적경형지중해빈혈잉전혹잉조기부녀95례（관찰조），선택동기재본원주원분면적430례임신합병결철성빈혈（대조조）화420례잉기혈홍단백정상잉부（정상조）。분별재잉부11～13주（잉조기）、24～28주（잉중기）화36～40주（잉만기）검측각조HGB화혈청SF함량，병비교각조임신결국。결과：관찰조잉조기、잉중기화잉만기HGB화SF분별위91．94±7．61g／L、86．39±6．84g／L、85．62±7．04g／L화76．47±5．62μg／L、52．18±5．14μg／L화40．82±5．10μg／L，균저우대조조화정상조，대조조저우정상조，차이구유통계학의의（P＜0．05）。관찰조HGB화SF하강폭도분별위6．24±1．03g／L화29．40±3．22μg／L，균고우대조조화정상조，차이구유통계학의의（ P＜0．05）。관찰조부궁산、양수과다／과소、조산인、족월저체중인화산후출혈분별위50．53％（48／95）、17．89％（17／95）、14．74％（14／95）、12．63％（12／95）화190．81±11．64mL，균고우대조조화정상조，차이구유통계학의의（P＜0．05）。관찰조신생인평균체중위190．81±11．64kg，균저우대조조화정상조，대조조저우정상조，차이구유통계학의의（ P＜0．05）。결론：경형지중해빈혈잉부임신기HGB、SF함량명현감소，차강저폭도현저증고，부궁산、조산인명현증가，신생인평균체중강저，대모영결국유일정적영향，응가강잉부적위산기보건。
Objective:To study the hemoglobin ( HGB) and serum ferritin ( SF) changes and clinical significance of the pregnant women with light mediterranean anemia , and analyze the influence on the preg-nancy outcome , to provide the basis of the pregnancy .Method:95 early pregnancy or pregnant women with light mediterranean anemia were selected in the hospital from January in 2013 to October in 2013 as the ob-servation group , 430 pregnant women with iron deficiency anemia ( the control group ) were selected in the same period and 420 cases of pregnant women with normal hemoglobin ( the normal group ) .To detect HGB and serum SF during pregnant 11~13 week (early pregnancy), 24~28 weeks(mid pregnancy) and 36~40 weeks ( late pregnancy ) , and compare the pregnancy outcome .Result:HGB and SF of the observation group in early pregnancy, mid pregnancy and late pregnancy were 91.94 ±7.61g/L, 86.39 ±6.84g/L, 85.62 ±7. 04g/L and 76.47 ±5.62μg/L, 52.18 ±5.14μg/L, 40.82 ±5.10μg/L, which was lower than the control group and the normal group , the control group was lower than those of normal group , the difference was sta-tistically significant ( P <0.05) .HGB and SF decreased of the observation group were 6.24 ±1.03g/L and 29.40 ±3.22μg/L respectively,higher than those of the control group and the normal group , the difference was statistically significant (P <0.05).The cesarean delivery, Polyhydramnios or less,premature, low birth weight infant and postpartum hemorrhage of the observation group were 50.53%( 48/95 ) , 17.89%( 17/95), 14.74%(14/95), 12.63%(12/95) and 190.81 ±11.64mL, higher than those of the control group and the normal group, the difference was statistically significant (P <0.05).The average weight of the neo-nates in the observation group was 190.81 ±11.64kg, lower than the control group and the normal group , the control group was lower than that in the normal group , the difference was statistically significant ( P <0. 05).Conclusion:HGB, SF of the pregnant women with light mediterranean anemia decrease significantly , and the decrease degree is significantly increased .The cesarean section , premature infants increase signifi-cantly, the average weight of newborn reduces , which has certain influence on pregnancy outcome of preg-nant women , should strengthen the perinatal care .
