CAJ | 학술논문

目的：研究老年急性脑梗死（ ACI）患者颈动脉粥样硬化（CAS）新危险因素，为CAS的防治提供参考。方法：将162例ACI患者根据是否发生CAS分为无斑块组70例，斑块组92例，分别检测血糖、血脂、胆红素、C反应蛋白（CRP）、尿酸（UA）、纤维蛋白原（Fib）浓度，对上述指标与颈动脉内－中膜厚度（ IMT）进行Spearman相关性分析。结果：两组血脂、血糖水平比较差异无统计学意义（ P＞0．05）；斑块组总胆红素（ TBIL）、间接胆红素（ IBIL）浓度低于无斑块组（ P＜0．05），CRP、UA、Fib浓度高于无斑块组（P＜0．05）；CRP、UA 、Fib 浓度与IMT 呈正相关（r1＝2．84，r2＝1．45，r3＝1．98，均P＜0．05）， TBIL、IBIL浓度与IMT呈负相关（ r4＝－0．74，r5＝－1．02，均P＜0．05）。结论：老年ACI 患者CRP、UA、Fib浓度升高参与了CAS发病与发展的过程，而TBIL、IBIL是IMT增厚的保护性因素。
목적：연구노년급성뇌경사（ ACI）환자경동맥죽양경화（CAS）신위험인소，위CAS적방치제공삼고。방법：장162례ACI환자근거시부발생CAS분위무반괴조70례，반괴조92례，분별검측혈당、혈지、담홍소、C반응단백（CRP）、뇨산（UA）、섬유단백원（Fib）농도，대상술지표여경동맥내－중막후도（ IMT）진행Spearman상관성분석。결과：량조혈지、혈당수평비교차이무통계학의의（ P＞0．05）；반괴조총담홍소（ TBIL）、간접담홍소（ IBIL）농도저우무반괴조（ P＜0．05），CRP、UA、Fib농도고우무반괴조（P＜0．05）；CRP、UA 、Fib 농도여IMT 정정상관（r1＝2．84，r2＝1．45，r3＝1．98，균P＜0．05）， TBIL、IBIL농도여IMT정부상관（ r4＝－0．74，r5＝－1．02，균P＜0．05）。결론：노년ACI 환자CRP、UA、Fib농도승고삼여료CAS발병여발전적과정，이TBIL、IBIL시IMT증후적보호성인소。
Objective:To study new risk factors for CAS in elderly patients with ACI ,so as to provide reference for prevention and treatment of CAS .Method: 162 patients with ACI were divided into without plaque group (70 cases) and plaque group (92 cases) according to whether occurred CAS or not .Detected blood glucose,blood lipids,bilirubin,CRP,UA,Fib,and spearman correlation analysis of these index and IMT.Result:Lipids,blood glucose level was no significant difference between two groups ( P>0.05);TBIL, IBIL concentrations in plaque group were less than those in without plaque group (P<0.05), CRP,UA,Fib concentrations were more than those in without plaque group ( P<0.05);CRP ,UA,Fib concentration was pos-itively correlated with IMT(r1=2.84,r2=1.45,r3=1.98,all P<0.05),TBIL,IBIL concentration was nega-tively correlated with IMT(r4=-0.74,r5=-1.02,both P<0.05).Conclusion: CRP,UA,Fib concentration in elderly patients with ACI involved in the CAS onset and development process ,and TBIL,IBIL is a protec-tive factor for IMT.