河北医学
河北醫學
하북의학
HEBEI MEDICINE
2015年
3期
440-442,443
,共4页
膜性肾病%肾病综合征%肾小球滤过率
膜性腎病%腎病綜閤徵%腎小毬濾過率
막성신병%신병종합정%신소구려과솔
Membranous nephropathy%Nephrotic syndrome%Glomerular filtration rate
目的：总结成人特发性膜性肾病临床病理特征及预后相关因素。方法：回顾性分析82例IMN患者临床、病理及随访资料，总结其临床病理特点，并以eGFR＜30mL／min为随访终点，将患者分为肾功能进展组及肾功能稳定组，比较两组患者临床资料。结果：82例患者中有肾病综合征者56例（68．29％），合并高血压31例（37．8％），病理分期I期25例（30．48％），Ⅱ期50例（60．98％），随访过程中有12例患者eGFR＜30mL／min，两组患者比较在平均动脉压、临床表现为肾病综合征比例、eGFR、胆固醇、24h尿蛋白定量、合并肾小管间质损害比例方面差异有统计学意义（ P＜0．05）。结论：成人特发性膜性肾病患者临床以肾病综合征多见，病理分期以Ⅰ期、Ⅱ期为主，高血压、临床出现肾病综合征、大量蛋白尿、肾功能损伤、高胆固醇血症及合并肾小管间质损害与IMN患者肾功能恶化进展有关。
目的：總結成人特髮性膜性腎病臨床病理特徵及預後相關因素。方法：迴顧性分析82例IMN患者臨床、病理及隨訪資料，總結其臨床病理特點，併以eGFR＜30mL／min為隨訪終點，將患者分為腎功能進展組及腎功能穩定組，比較兩組患者臨床資料。結果：82例患者中有腎病綜閤徵者56例（68．29％），閤併高血壓31例（37．8％），病理分期I期25例（30．48％），Ⅱ期50例（60．98％），隨訪過程中有12例患者eGFR＜30mL／min，兩組患者比較在平均動脈壓、臨床錶現為腎病綜閤徵比例、eGFR、膽固醇、24h尿蛋白定量、閤併腎小管間質損害比例方麵差異有統計學意義（ P＜0．05）。結論：成人特髮性膜性腎病患者臨床以腎病綜閤徵多見，病理分期以Ⅰ期、Ⅱ期為主，高血壓、臨床齣現腎病綜閤徵、大量蛋白尿、腎功能損傷、高膽固醇血癥及閤併腎小管間質損害與IMN患者腎功能噁化進展有關。
목적：총결성인특발성막성신병림상병리특정급예후상관인소。방법：회고성분석82례IMN환자림상、병리급수방자료，총결기림상병리특점，병이eGFR＜30mL／min위수방종점，장환자분위신공능진전조급신공능은정조，비교량조환자림상자료。결과：82례환자중유신병종합정자56례（68．29％），합병고혈압31례（37．8％），병리분기I기25례（30．48％），Ⅱ기50례（60．98％），수방과정중유12례환자eGFR＜30mL／min，량조환자비교재평균동맥압、림상표현위신병종합정비례、eGFR、담고순、24h뇨단백정량、합병신소관간질손해비례방면차이유통계학의의（ P＜0．05）。결론：성인특발성막성신병환자림상이신병종합정다견，병리분기이Ⅰ기、Ⅱ기위주，고혈압、림상출현신병종합정、대량단백뇨、신공능손상、고담고순혈증급합병신소관간질손해여IMN환자신공능악화진전유관。
Objective:To summarize the clinical pathological features and prognostic factors of adult idi-opathic membranous nephropathy (IMN).Method:Clinical, pathological and follow-up data of 82 patients with IMN was analyzed retrospectively , the clinical and pathological features were summarized , and end of follow-up was eGFR <30 mL/min, The patients were divided into groups of renal function steady and renal function progress, clinical data was compared.Result: In 82 patients,there were 56 cases (68.29%)with nephrotic syndrome , 31 cases ( 37.8%) with hypertension , pathological stage I was 25 cases ( 30.48%) ,stage Ⅱwas 50 cases (60.98%), in the follow-up process, there were 12 cases of patients with eGFR <30 mL /min, comparing two groups of patients ,there's statistically significant in mean arterial pressure , the proportion of nephrotic syndrome clinical manifestations , eGFR, cholesterol, 24h urine protein, interstitial renal tubular damage (P <0.05).Conclusion:Nephrotic syndrome is the most common clinical manifesta-tions in patients with IMN , the most common pathological stage is I and II , and hypertension , nephrotic syn-drome, proteinuria, renal damage, hypercholesterolemia and interstitial renal tubular damage is associated with the progress of renal function in patients with IMN .
