河北医学
河北醫學
하북의학
HEBEI MEDICINE
2015年
3期
428-431
,共4页
吴栋良%宫计划%陈燕%杨永铭
吳棟良%宮計劃%陳燕%楊永銘
오동량%궁계화%진연%양영명
复方丹参滴丸%厄贝沙坦%老年早期2型糖尿病肾病%尿微量白蛋白
複方丹參滴汍%阨貝沙坦%老年早期2型糖尿病腎病%尿微量白蛋白
복방단삼적환%액패사탄%노년조기2형당뇨병신병%뇨미량백단백
Compond Danshen dripping pill%Irbesartan%Elderly type 2 diabetic nephropathy%Microalbuminuria
目的:探讨复方丹参滴丸联合厄贝沙坦对老年早期2型糖尿病肾病患者尿微量白蛋白的影响。方法:选择肾内科诊治的60例老年早期2型糖尿病肾病患者纳入本研究,将其分为观察组和对照组,各30例。对照组服用厄贝沙坦,而观察组服用复方丹参滴丸联合厄贝沙坦,对两组患者治疗前后血液流变学的变化、生化指标及UAER的变化进行分析。结果:对照组患者治疗前,TC、TG、Scr、BUN及UAER为6.5±0.5、2.5±0.4、80±10μmoL/L、5.7±1.7mmoL/L及111.4±191.2μg/min,治疗后,各指标为6.5±0.4、2.4±0.3、78±9μmoL/L、5.6±1.3mmoL/L及73.2±9.1μg/min,对各指标及血液流变学对比分析后,差异无统计学意义(P>0.05);而观察组患者在治疗前后各指标分别为6.5±0.6、2.6±0.4、78±11μmoL/L、6.0±1.5mmoL/L及112.8±0.3μg/min和4.8±0.6、1.5±0.2、75±12μmoL/L、5.7±1.4mmoL/L及60.1±9.5μg/min,均有所降低,对各指标及血液流变学对比分析后,差异有统计学意义(P<0.05)。结论:厄贝沙坦联合复方丹参滴丸对于老年早期2型糖尿病肾病患者具有显著的疗效。
目的:探討複方丹參滴汍聯閤阨貝沙坦對老年早期2型糖尿病腎病患者尿微量白蛋白的影響。方法:選擇腎內科診治的60例老年早期2型糖尿病腎病患者納入本研究,將其分為觀察組和對照組,各30例。對照組服用阨貝沙坦,而觀察組服用複方丹參滴汍聯閤阨貝沙坦,對兩組患者治療前後血液流變學的變化、生化指標及UAER的變化進行分析。結果:對照組患者治療前,TC、TG、Scr、BUN及UAER為6.5±0.5、2.5±0.4、80±10μmoL/L、5.7±1.7mmoL/L及111.4±191.2μg/min,治療後,各指標為6.5±0.4、2.4±0.3、78±9μmoL/L、5.6±1.3mmoL/L及73.2±9.1μg/min,對各指標及血液流變學對比分析後,差異無統計學意義(P>0.05);而觀察組患者在治療前後各指標分彆為6.5±0.6、2.6±0.4、78±11μmoL/L、6.0±1.5mmoL/L及112.8±0.3μg/min和4.8±0.6、1.5±0.2、75±12μmoL/L、5.7±1.4mmoL/L及60.1±9.5μg/min,均有所降低,對各指標及血液流變學對比分析後,差異有統計學意義(P<0.05)。結論:阨貝沙坦聯閤複方丹參滴汍對于老年早期2型糖尿病腎病患者具有顯著的療效。
목적:탐토복방단삼적환연합액패사탄대노년조기2형당뇨병신병환자뇨미량백단백적영향。방법:선택신내과진치적60례노년조기2형당뇨병신병환자납입본연구,장기분위관찰조화대조조,각30례。대조조복용액패사탄,이관찰조복용복방단삼적환연합액패사탄,대량조환자치료전후혈액류변학적변화、생화지표급UAER적변화진행분석。결과:대조조환자치료전,TC、TG、Scr、BUN급UAER위6.5±0.5、2.5±0.4、80±10μmoL/L、5.7±1.7mmoL/L급111.4±191.2μg/min,치료후,각지표위6.5±0.4、2.4±0.3、78±9μmoL/L、5.6±1.3mmoL/L급73.2±9.1μg/min,대각지표급혈액류변학대비분석후,차이무통계학의의(P>0.05);이관찰조환자재치료전후각지표분별위6.5±0.6、2.6±0.4、78±11μmoL/L、6.0±1.5mmoL/L급112.8±0.3μg/min화4.8±0.6、1.5±0.2、75±12μmoL/L、5.7±1.4mmoL/L급60.1±9.5μg/min,균유소강저,대각지표급혈액류변학대비분석후,차이유통계학의의(P<0.05)。결론:액패사탄연합복방단삼적환대우노년조기2형당뇨병신병환자구유현저적료효。
Objective: To investigate the impact of compound Danshen dripping pills combined with irbesartan for elderly type 2 diabetic nephropathy early microalbuminuria .Method:60 patients with elderly type 2 diabetic nephropathy early microalbuminuria were chosen in our hospital to receive treatment , divided into two groups, with 30 patients in each group respectively .Patients in the control group were treated with irbesartan, and patients in the observation group were treated with compound Danshen dripping pills com-bined with irbesartan .Before and after treatment , the change in blood rheology , and biochemical parameters and changes in UAER two groups of patients were analyzed .Result: The control group of patients before treatment, TC, TG, Scr, BUN and UAER was 6.5 ±0.5,2.5 ±0.4,80 ±10μmoL /L, 5.7 ±1.7 mmoL /L and 111.4 ±191.2μg/min, after treatment, all indicators 6.5 ±0.4,2.4 ±0.3,78 ±9μmoL /L, 5.6 ±1. 3 mmoL /L and 73.2 ±9.1μg/min, after each index and blood rheology comparative analysis , the differ-ence was not statistically significant ( P>0.05) ;while observing patients before and after treatment of each index were 6.5 ±0.6,2.6 ±0.4,78 ±11μmoL /L, 6.0 ±1.5mmoL /L and 112.8 ±0.3μg/min and 4.8 ± 0.6,1.5 ±0.2,75 ±12μmoL /L, 5.7 ±1.4mmoL /L and 60.1 ±9.5μg/min, were decreased after each index and blood rheology comparative analysis , the difference was statistically significant (P <0.05).Con-clusion:Irbesartan joint compound Danshen dripping pills for early type 2 diabetic nephropathy in elderly patients have a significant effect .