CAJ | 학술논문

目的：观察原发性肾病综合征（primary nephritic syndrome ，PNS）与血小板活化因子水解酶（ platelet activating factor cetylhydrolase ，PAF－AH）相关性关系。方法：选择2013年1月至2013年6月收治的原发性肾病综合征患者48例作为研究对象，均为初治患者，分为单纯性肾病综合征组（ STNS组）31例及肾炎型肾病综合征组（ NTNS组）17例；并根据对激素治疗效应差异分为激素敏感型肾病综合征（ steroid－sensitive nephritic syndrome ，SSNS）组19例，激素耐药型肾病综合征（ steroid－resistent ne-phritic syndrome ， SRNS ）组15例，激素依赖型肾病综合征组（ steroid－dependent nephritic syndrome ， SDNS）组14例，选择本院体检健康人员30例作为对照组，78例入选对象均测定PAF－AH活性，比较各组之间差异。结果：STNS组PAF－AH活性为（51．9±8．3）umoL· min－1· L－1，均高于NTNS组及健康对照组，均P＜0．05；且NTNS组PAF－AH活性高于健康对照组，均P＜0．05。 SSNS组PAF－AH活性均高于SRNS组、SDNS组、对照组，均P＜0．05，且SRNS组、SDNS组PAF－AH活性均高于对照组，均P＜0．05。经perason分析，PAF－AH活性与原发性肾病综合征之间有明显相关分析，其中，rSTNS＝0．618；rNTNS＝0．524；rSSNS＝0．717；rSRNS＝0．567．；rSDNS＝0．327，P＜0．05。结论：原发性肾病综合征患者血小板活化因子水解酶活性显著高于正常人群，且不同类型PNS患者PAF－AH活性不同．
목적：관찰원발성신병종합정（primary nephritic syndrome ，PNS）여혈소판활화인자수해매（ platelet activating factor cetylhydrolase ，PAF－AH）상관성관계。방법：선택2013년1월지2013년6월수치적원발성신병종합정환자48례작위연구대상，균위초치환자，분위단순성신병종합정조（ STNS조）31례급신염형신병종합정조（ NTNS조）17례；병근거대격소치료효응차이분위격소민감형신병종합정（ steroid－sensitive nephritic syndrome ，SSNS）조19례，격소내약형신병종합정（ steroid－resistent ne-phritic syndrome ， SRNS ）조15례，격소의뢰형신병종합정조（ steroid－dependent nephritic syndrome ， SDNS）조14례，선택본원체검건강인원30례작위대조조，78례입선대상균측정PAF－AH활성，비교각조지간차이。결과：STNS조PAF－AH활성위（51．9±8．3）umoL· min－1· L－1，균고우NTNS조급건강대조조，균P＜0．05；차NTNS조PAF－AH활성고우건강대조조，균P＜0．05。 SSNS조PAF－AH활성균고우SRNS조、SDNS조、대조조，균P＜0．05，차SRNS조、SDNS조PAF－AH활성균고우대조조，균P＜0．05。경perason분석，PAF－AH활성여원발성신병종합정지간유명현상관분석，기중，rSTNS＝0．618；rNTNS＝0．524；rSSNS＝0．717；rSRNS＝0．567．；rSDNS＝0．327，P＜0．05。결론：원발성신병종합정환자혈소판활화인자수해매활성현저고우정상인군，차불동류형PNS환자PAF－AH활성불동．
Objective:To observe the correlation of primary nephrotic syndrome ( primary nephritic syn-drome,PNS) with platelet activating factor acetylhydrolase (platelet activating factor cetylhydrolase ,PAF-AH).Method:48 patients with primary nephrotic syndrome treated in the hospital from Jan .2013 to Jun. 2013 were selected as the research object , all were initial treatment patients .They were divided into simple nephrotic syndrome group (STNS group with 31 cases) and nephritic type nephrotic syndrome group (NTNS group with 17 cases);and according to the difference in effects of hormone treatment all patients were divided sensitive nephrotic syndrome ( steroid-sensitive nephritic syndrome , SSNS ) group ( 19 cases ) , steroid re-sistant nephrotic syndrome (steroid-resistent nephritic syndrome, SRNS) group (15 cases), steroid depend-ent nephrotic syndrome group ( steroid-dependent nephritic syndrome , SDNS ) group ( 14 cases ) , then se-lected healthy persons with 30 cases as control group , 78 cases were determined the activity of PAF-AH, then compared differences between two groups .Result:PAF-AH activity in STNS group was(51.9 ±8.3)μmoL· min-1 · L-1 and was higher than those in NTNS group and healthy control group , all P<0.05; and NTNS activity in PAF-AH group were higher than that in healthy control group , all P<0.05.The activity of PAF-AH in SSNS group were higher than those in SRNS group , SDNS group and the control group , P<0.05 group, SDNS group, SRNS and PAF-AH activity were higher than the control group , all P<0.05.By the a-nalysis of perason , PAF-AH activity and primary nephrotic syndrome had obvious correlation analysis ,rSTNS=0.618;rNTNS=0.524; rSSNS=0.717; rSRNS=0.567.; rSDNS=0.327, P<0.05.Conclusion: Platelet activating factor acetylhydrolase activity of patients with nephrotic syndrome is significantly higher than the normal population, and the different types of PNS patients ’ PAF-AH activity are different.