CAJ | 학술논문

目的：探讨艾塞那肽联合二甲双胍治疗口服降糖药控制不佳的超重或肥胖2型糖尿病（ T2DM）患者的临床疗效。方法：选择口服降糖药后血糖控制不佳的超重或肥胖T2DM患者24例，予艾塞那肽联合二甲双胍治疗，比较治疗前后体重、腰围、血压、BMI、血脂、血糖控制及胰岛素分泌指数（ HOMA－％B）、胰岛素抵抗指数（ HOMA－IR）的变化。结果：治疗后患者体重、BMI、腰围、SBP、DBP、FBG、2hPBG、TC、TG、HbA1c、HOMA－IR较治疗前均显著降低，而空腹C肽及HOMA－％B较治疗前升高，差异均有统计学意义（ P＜0．05）；胃肠道反应为最常见的不良反应，且无严重低血糖反应。结论：艾塞那肽联合二甲双胍治疗口服降糖药控制不佳的超重或肥胖T2DM患者，可有效控血糖，降低体重，改善血脂代谢及β细胞功能和减轻胰岛素抵抗，且低血糖反应发生率低，是一种安全有效的理想治疗方案。
목적：탐토애새나태연합이갑쌍고치료구복강당약공제불가적초중혹비반2형당뇨병（ T2DM）환자적림상료효。방법：선택구복강당약후혈당공제불가적초중혹비반T2DM환자24례，여애새나태연합이갑쌍고치료，비교치료전후체중、요위、혈압、BMI、혈지、혈당공제급이도소분비지수（ HOMA－％B）、이도소저항지수（ HOMA－IR）적변화。결과：치료후환자체중、BMI、요위、SBP、DBP、FBG、2hPBG、TC、TG、HbA1c、HOMA－IR교치료전균현저강저，이공복C태급HOMA－％B교치료전승고，차이균유통계학의의（ P＜0．05）；위장도반응위최상견적불량반응，차무엄중저혈당반응。결론：애새나태연합이갑쌍고치료구복강당약공제불가적초중혹비반T2DM환자，가유효공혈당，강저체중，개선혈지대사급β세포공능화감경이도소저항，차저혈당반응발생솔저，시일충안전유효적이상치료방안。
Objective:To investigate the efficacy of exenatide combined with metformin in patients of o-verweight or obesity with type 2 diabetes inadequately controlled in blood glucose .Method:24 patients of o-verweight or obesity with type 2 diabetes inadequately controlled in blood glucose were treated by exenatide combined with metformin ,the body weight , waistline,blood pressure ,lipids,blood glucose control and insu-lin secretion index (HOMA-%B), insulin resistance index (HOMA-IR) changes were compared after treatment.Result:After treatment ,the body weight,Wt,BMI,SBP,DBP,TC,TG, FBG, 2h PBG, HbA1c, HOMA-IR were significantly lower , and the fasting C-peptide and HOMA-%B were increased , the differ-ence was statistically significant ( P<0.05 );the most common adverse reactions was gastrointestinal tract , and there's no severe hypoglycemic reaction .Conclusion: The treatment of exenatide combined with met-formin in patients of overweight or obesity with type 2 diabetes inadequately controlled in blood glucose can effectively control blood glucose , reduce body weight , improve lipid metabolism and β-cell function and re-duce the insulin resistance , and with low incidence of hypoglycemia ,it is a safe and effective method .