CAJ | 학술논문

脂肪组织可以通过分泌脂肪因子介导胰岛素抵抗、炎症调控、内皮功能障碍及动脉粥样硬化等异常。近年来逐渐认识到银屑病是一种系统性疾病，与肥胖、高血压、糖尿病及代谢综合征等相关。脂肪因子抵抗素、内脂素、网膜素及视黄醇结合蛋白4等在银屑病等皮肤病中表达异常，可能参与银屑病发病机制中的免疫应答及表皮异常增殖。
지방조직가이통과분비지방인자개도이도소저항、염증조공、내피공능장애급동맥죽양경화등이상。근년래축점인식도은설병시일충계통성질병，여비반、고혈압、당뇨병급대사종합정등상관。지방인자저항소、내지소、망막소급시황순결합단백4등재은설병등피부병중표체이상，가능삼여은설병발병궤제중적면역응답급표피이상증식。
Adipose tissue may mediate the development of insulin resistance, inflammation, endothelial dysfunction and atherosclerosis by secreting adipokines. Recently, psoriasis has been gradually recognized as a sys-temic disease frequently associated with metabolic disorders including obesity, hypertension, diabetes and metabolic syndrome. There is an abnormal expression of adipokines such as resistin,visfatin, omentin and retinol binding protein 4 in patients with psoriasis, which may be involved in the abnormal immune response and keratinocyte proliferation in psoriasis.