CAJ | 학술논문

特应性性皮炎( AD)病因以及发病机制复杂，目前仍未完全明确。活化T淋巴细胞浸润为AD患者皮肤炎症皮损处特征，但是，目前仍不清楚浸润的是哪些T淋巴细胞亚群，如何被参与招募并聚集在皮损部位，发挥什么样免疫损伤作用。免疫学研究显示，趋化因子对于淋巴细胞的招募、聚集并发挥炎症反应至关重要。趋化因子是一类具有趋化活性的细胞因子，在机体的免疫调节、过敏反应、炎症反应、细胞增殖分化等过程中发挥重要作用，因此，本文围绕CKLF1(趋化素样因子1)与T淋巴细胞亚群及功能之间的关系，就CKLF-1在特应性皮炎发病机制中的研究进展作一综述。
특응성성피염( AD)병인이급발병궤제복잡，목전잉미완전명학。활화T림파세포침윤위AD환자피부염증피손처특정，단시，목전잉불청초침윤적시나사T림파세포아군，여하피삼여초모병취집재피손부위，발휘십요양면역손상작용。면역학연구현시，추화인자대우림파세포적초모、취집병발휘염증반응지관중요。추화인자시일류구유추화활성적세포인자，재궤체적면역조절、과민반응、염증반응、세포증식분화등과정중발휘중요작용，인차，본문위요CKLF1(추화소양인자1)여T림파세포아군급공능지간적관계，취CKLF-1재특응성피염발병궤제중적연구진전작일종술。
Etiology and pathogenesis of atopic dermatitis ( AD) is complicated and remains unclear. The infiltra-tion of activated T lymphocytes is characteristic of the AD inflammatory skin lesion. However, what T lymphocyte sub-group involved, how they are recruited and gathered at the lesion site, its contribution to the immune injury, is still unclear. Immunological studies indicated that chemokines play an important role for lymphocyte recruitment, gather in and inflammatory response. Therefore, the progress of CKLF-1 in the pathogenesis of AD with regard to the relation-ship between CKLF1 ( chemokine like factor 1) and T lymphocyte subsets was reviewed in this paper.