国际妇产科学杂志
國際婦產科學雜誌
국제부산과학잡지
JOURNAL OF INTERNATIONAL OBSTETRICS AND GYNECOLOGY
2014年
6期
680-682
,共3页
子宫内膜增生%左炔诺孕酮%宫内避孕器%迟效制剂%血流动力学
子宮內膜增生%左炔諾孕酮%宮內避孕器%遲效製劑%血流動力學
자궁내막증생%좌결낙잉동%궁내피잉기%지효제제%혈류동역학
Endometrial hyperplasia%Levonorgestrel%Intrauterine devices%Delayed-action preparations%Hemodynamics
目的：探讨左炔诺孕酮宫内缓释系统（曼月乐）治疗子宫内膜单纯性增生过长的疗效及可能作用机制。方法：选取2011年11月—2012年2月门诊应用曼月乐治疗子宫内膜单纯性增生过长的患者60例，观察放置曼月乐6个月后的子宫内膜活检病理变化及经阴道超声测量子宫内膜厚度、子宫动脉血流[阻力指数（RI）、搏动指数（PI）]及月经模式的改变。结果：2例由于阴道持续性点滴出血提前取出，58例子宫内膜转归正常。放置曼月乐前后子宫内膜厚度、RI分别为（1.52±0.33） cm、（0.62±0.14）cm和0.64±0.07、0.79±0.08，差异均有统计学意义（P＜0.05或P＜0.01），PI分别为1.98±0.51、1.96±0.04，差异无统计学意义（P＞0.05)。放置曼月乐后经量明显减少，24例表现为月经稀发，32例表现为闭经。结论：曼月乐是治疗子宫内膜单纯性增生过长的简单有效方法，对子宫动脉血流的影响是其可能的作用机制。
目的：探討左炔諾孕酮宮內緩釋繫統（曼月樂）治療子宮內膜單純性增生過長的療效及可能作用機製。方法：選取2011年11月—2012年2月門診應用曼月樂治療子宮內膜單純性增生過長的患者60例，觀察放置曼月樂6箇月後的子宮內膜活檢病理變化及經陰道超聲測量子宮內膜厚度、子宮動脈血流[阻力指數（RI）、搏動指數（PI）]及月經模式的改變。結果：2例由于陰道持續性點滴齣血提前取齣，58例子宮內膜轉歸正常。放置曼月樂前後子宮內膜厚度、RI分彆為（1.52±0.33） cm、（0.62±0.14）cm和0.64±0.07、0.79±0.08，差異均有統計學意義（P＜0.05或P＜0.01），PI分彆為1.98±0.51、1.96±0.04，差異無統計學意義（P＞0.05)。放置曼月樂後經量明顯減少，24例錶現為月經稀髮，32例錶現為閉經。結論：曼月樂是治療子宮內膜單純性增生過長的簡單有效方法，對子宮動脈血流的影響是其可能的作用機製。
목적：탐토좌결낙잉동궁내완석계통（만월악）치료자궁내막단순성증생과장적료효급가능작용궤제。방법：선취2011년11월—2012년2월문진응용만월악치료자궁내막단순성증생과장적환자60례，관찰방치만월악6개월후적자궁내막활검병리변화급경음도초성측양자궁내막후도、자궁동맥혈류[조력지수（RI）、박동지수（PI）]급월경모식적개변。결과：2례유우음도지속성점적출혈제전취출，58례자궁내막전귀정상。방치만월악전후자궁내막후도、RI분별위（1.52±0.33） cm、（0.62±0.14）cm화0.64±0.07、0.79±0.08，차이균유통계학의의（P＜0.05혹P＜0.01），PI분별위1.98±0.51、1.96±0.04，차이무통계학의의（P＞0.05)。방치만월악후경량명현감소，24례표현위월경희발，32례표현위폐경。결론：만월악시치료자궁내막단순성증생과장적간단유효방법，대자궁동맥혈류적영향시기가능적작용궤제。
Objective:To study the efficancy and long possible mechanism of Mirena (levonorgestrel intrauterine system ) in the treatment of simple endometrial hyperplasia. Methods:Select sixty cases of simple endometrial hyperplasia in outpatient between 2011.11 and 2012.2,we observed the menstrual patterns,the endometrial thickness and uterine arterial blood flow [resistance index (RI),pulsatility index (PI)] by transvaginal ultrasound,pathologic changes of endometrial by endometrial biopsy in 6 months after insertion of mirena. Results:2 patients were removed Mirena due to colporrhagia. Pathological examinations of 58 patients performed 6 months after the insertion showed that endometrial hyperplasia had reversed. The endometrial thickness,RI of uterine artery in 6 months after the insertion were statistically significant,respectively (1.52±0.33) cm,(0.62±0.14) cm (P<0.05) and 0.64±0.07,0.79±0.08 (P<0.01);PI was 1.98±0.51,1.96±0.04,the difference was not statistically significant(P>0.05). After placing Mirena significantly reduced by the amount,24 cases showed oligomenorrhea,32 cases showed amenorrhea. Conclusions:Mirena is an efficient and simple treatment of simple endometrial hyperplasia. The influence of uterine arterie blood flow is its possible mechanism.
