国际妇产科学杂志
國際婦產科學雜誌
국제부산과학잡지
JOURNAL OF INTERNATIONAL OBSTETRICS AND GYNECOLOGY
2014年
6期
667-669
,共3页
乳头状瘤病毒科%人乳头瘤病毒16%宫颈疾病%免疫组织化学
乳頭狀瘤病毒科%人乳頭瘤病毒16%宮頸疾病%免疫組織化學
유두상류병독과%인유두류병독16%궁경질병%면역조직화학
Papillomaviridae%Human papillomavirus 16%Uterine cervical diseases%Immunohistochemistry
目的:分析人乳头瘤病毒(HPV)分型与HPV L1蛋白联合检测在判断宫颈疾病预后中的临床意义。方法:选择2011年1月—2012年7月在皖南医学院第一附属医院妇科门诊检测HPV分型高危型阳性,液基薄层细胞学(TCT)检查≥未明确诊断意义的不典型鳞状上皮细胞(ASCUS),最后经组织病理确诊的114例患者作为研究对象,用免疫组化法检测HPV L1蛋白的表达情况,分析HPV亚型、L1蛋白及病理结果之间的关系。结果:在炎症、宫颈上皮内瘤变Ⅰ(CINⅠ)、CINⅡ/Ⅲ和鳞状细胞癌(SCC)中,HPV L1蛋白阳性率分别为64.3%(27/42)、54.5%(6/11)、15.7%(8/51)、0(0/10),HPV L1蛋白阳性率随着宫颈上皮病变加重而逐渐降低(P<0.05)。在114例患者中,HPV16感染阳性最多,占50%(57/114),其次分别为52型(14.91%)、58型(14.04%)、18型(7.89%)。 HPV L1蛋白在HPV16和18亚型中呈低表达,在52、58亚型中呈高表达,且在感染HPV52、58亚型患者中L1蛋白阳性组中炎症所占的比例明显高于L1蛋白阴性组中的比例,差异有统计学意义(P<0.05)。结论:HPV L1蛋白的检测有助于判断宫颈疾病的程度及恶性进展趋势,联合HPV分型检测对其预后和处理有一定的指导意义。
目的:分析人乳頭瘤病毒(HPV)分型與HPV L1蛋白聯閤檢測在判斷宮頸疾病預後中的臨床意義。方法:選擇2011年1月—2012年7月在皖南醫學院第一附屬醫院婦科門診檢測HPV分型高危型暘性,液基薄層細胞學(TCT)檢查≥未明確診斷意義的不典型鱗狀上皮細胞(ASCUS),最後經組織病理確診的114例患者作為研究對象,用免疫組化法檢測HPV L1蛋白的錶達情況,分析HPV亞型、L1蛋白及病理結果之間的關繫。結果:在炎癥、宮頸上皮內瘤變Ⅰ(CINⅠ)、CINⅡ/Ⅲ和鱗狀細胞癌(SCC)中,HPV L1蛋白暘性率分彆為64.3%(27/42)、54.5%(6/11)、15.7%(8/51)、0(0/10),HPV L1蛋白暘性率隨著宮頸上皮病變加重而逐漸降低(P<0.05)。在114例患者中,HPV16感染暘性最多,佔50%(57/114),其次分彆為52型(14.91%)、58型(14.04%)、18型(7.89%)。 HPV L1蛋白在HPV16和18亞型中呈低錶達,在52、58亞型中呈高錶達,且在感染HPV52、58亞型患者中L1蛋白暘性組中炎癥所佔的比例明顯高于L1蛋白陰性組中的比例,差異有統計學意義(P<0.05)。結論:HPV L1蛋白的檢測有助于判斷宮頸疾病的程度及噁性進展趨勢,聯閤HPV分型檢測對其預後和處理有一定的指導意義。
목적:분석인유두류병독(HPV)분형여HPV L1단백연합검측재판단궁경질병예후중적림상의의。방법:선택2011년1월—2012년7월재환남의학원제일부속의원부과문진검측HPV분형고위형양성,액기박층세포학(TCT)검사≥미명학진단의의적불전형린상상피세포(ASCUS),최후경조직병리학진적114례환자작위연구대상,용면역조화법검측HPV L1단백적표체정황,분석HPV아형、L1단백급병리결과지간적관계。결과:재염증、궁경상피내류변Ⅰ(CINⅠ)、CINⅡ/Ⅲ화린상세포암(SCC)중,HPV L1단백양성솔분별위64.3%(27/42)、54.5%(6/11)、15.7%(8/51)、0(0/10),HPV L1단백양성솔수착궁경상피병변가중이축점강저(P<0.05)。재114례환자중,HPV16감염양성최다,점50%(57/114),기차분별위52형(14.91%)、58형(14.04%)、18형(7.89%)。 HPV L1단백재HPV16화18아형중정저표체,재52、58아형중정고표체,차재감염HPV52、58아형환자중L1단백양성조중염증소점적비례명현고우L1단백음성조중적비례,차이유통계학의의(P<0.05)。결론:HPV L1단백적검측유조우판단궁경질병적정도급악성진전추세,연합HPV분형검측대기예후화처리유일정적지도의의。
Objective:To analyze the relationship between the two methods and pathological results. Methods:Totally 114 patients who had the results of positive high-risk HPV,pathology and thin-prep liquid-based cytology(TCT) test diagnosed of a typical squamous cells of undetermined significance (ASCUS) and above in the First Affiliated Hospital of Wannan Medical College gynecology clinic from January 2011 to July 2012 were analyzed retrospectively. The expression of HPV L1 were detected in cervical lesions. We analyze the relationship between the subtypes of HPV ,HPV L1 capsid protein and pathological results. Results:The positive expression rate of HPV L1 was 64.3%(27/42),54.5%(6/11),15.7%(8/51),0(0/10) in cervictis, CINⅠ,CINⅡ/Ⅲ,SCC,HPV L1 capsid protein expression gradually decreased with cervical lesions increased. The most common HPV subtypes among the 114 patients were HPV16 (50%),HPV52 (14.91%),HPV58 (14.04%),HPV18 (7.89%), respectively. In the single infection 16 and 18 subtypes of HPV, HPV L1 protein negative rate in L1 protein rate was low expression,but highly expression in 52,58 subtypes. And in cervical tissue infected with HPV52 and HPV58, HPV L1 protein positive expression group finally confirmed by pathology of inflammation was significantly higher than that of negative group (P<0.05). Conclusions:The HPV L1 testing is useful in evaluation of cervical lesions and progression risk of cervical dysplasia ,the combination of both HPV L1 and HPV DNA detection can be helpful in management and prognostic prediction.