CAJ | 학술논문

目的：研究甘肃地区汉族女性DNA甲基转移酶1（DNMT1）基因多态性和被动吸烟与宫颈癌的相关性。方法：采用病例对照研究方法，选取甘肃地区100例宫颈癌患者和100例健康对照者，应用聚合酶链反应和基因测序法检测DNMT1基因多态性，比较不同基因型、被动吸烟与宫颈癌之间的关系。结果：被动吸烟者发生宫颈癌的相对危险性是无被动吸烟者的2.705倍（P＜0.05）；宫颈癌组rs16999593位点C等位基因频率高于对照组（P＜0.05）。结论：DNMT1基因的单核苷酸多态性和被动吸烟增加了宫颈癌的发病风险。
목적：연구감숙지구한족녀성DNA갑기전이매1（DNMT1）기인다태성화피동흡연여궁경암적상관성。방법：채용병례대조연구방법，선취감숙지구100례궁경암환자화100례건강대조자，응용취합매련반응화기인측서법검측DNMT1기인다태성，비교불동기인형、피동흡연여궁경암지간적관계。결과：피동흡연자발생궁경암적상대위험성시무피동흡연자적2.705배（P＜0.05）；궁경암조rs16999593위점C등위기인빈솔고우대조조（P＜0.05）。결론：DNMT1기인적단핵감산다태성화피동흡연증가료궁경암적발병풍험。
Objective:To evaluate the possible relationship between DNA methyctransferase 1 (DNMT1)gene polymor-phisms and passive smoking with cervical cancer in Han population of Gansu province,China. Methods:A case-control study, DNMT1 gene polymorphism were detected by PCR and gene sequencing method in 100 patients of cervical cancer in Gansu province and 100 healthy controls. The relationship between different genotypes ,passive smoking conditions and the risk of cer-vical cancer was analyzed. Results:Passive smoking has increased risk of developing cervical cancer by 2.705 times (P<0.05);the frequency of C allele of rs16999593 in cervical cancer patients was significantly higher than that in control group (P<0.05). Conclusions:These findings suggest that DNMT 1 gene polymorphism and passive smoking increased risk of cervical cancer.